MT VET COBRE II CORE C: ANIMAL MODELS

MT VET COBRE II CORE C：动物模型

• 批准号: 8360160
• 负责人: David W Pascual
• 金额: $ 12.63万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360160
• 关键词: Animal Model; Animals; Autoimmune Diseases; Biological Factors; Brucella; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Certification; Communicable Diseases; Coxiella; Development; Disease; Emerging Communicable Diseases; Funding; Grant; Laboratory Animal Production and Facilities; National Center for Complementary and Alternative Medicine; National Center for Research Resources; Organism; Pathogenesis; Preparation; Principal Investigator; Progress Reports; Protocols documentation; Report (document); Reporting; Research; Research Infrastructure; Research Personnel; Resources; Source; United States National Institutes of Health; Work; base; biodefense; biosafety level 3 facility; cost; design; falls; member; methionylmethionine; programs; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, and assist in protocol preparation and insure approvals are on file prior to any animal use. COBRE II This reporting year marks the second full year of COBRE II, where Core C replaced and transitioned from the BSL-3 Core (Core D), which was part of the initial COBRE I. The development and expansion of Core C was the result of extensive discussion with the EAC during the Fall 2008 review. Based on input from the EAC members and the COBRE II Project Leaders, the Animal Models Core was conceptualized and created. Core C continues to make strides on and benefits from the earlier work completed and started during COBRE I. From this era, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five-year study of natural products' impact on reducing infectious and autoimmune diseases. In the following sections, the subproject progress report documents how Core C continued to build on past successes and benefitted from its reorganization.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 动物模型核心（核心 C）由 David Pascual 博士指导，提供资源和专业知识，以满足 COBRE II 初级研究人员和与该中心相关的其他研究人员的需求，这些研究人员提议在其研究中使用动物模型和/或者需要专业知识和建议来实施新的动物模型，以加强/扩大他们的研究计划。核心 C 旨在 (a) 为项目负责人和利用传染病发病机制动物模型的其他中心研究人员提供技术、方法和分析支持，(b) 提供资源和专业知识以协助中心研究人员利用和/或开发新动物模型以增强或扩展其研究计划，(c) 方便中心研究人员进入 BSL-3 和 ABSL-2 动物研究设施，并协助方案准备并确保在任何动物使用之前获得批准。 科布雷II 本报告年是 COBRE II 的第二个完整年度，其中 Core C 取代了 BSL-3 Core（Core D）并从 BSL-3 Core（Core D）过渡，后者是最初 COBRE I 的一部分。Core C 的开发和扩展是广泛的结果2008 年秋季审查期间与 EAC 的讨论。根据 EAC 成员和 COBRE II 项目负责人的意见，动物模型核心被概念化和创建。核心 C 继续取得进展，并受益于 COBRE I 期间完成和开始的早期工作。从这个时代起，建立了 BSL-3 核心，以开发人畜共患疾病研究中心研究人员进行研究所需的必要资源和设施。 BSL-3 生物体。该中心在 COBRE I 期间完成了最先进的 BSL-3 设施的建设。该设施的竣工和 CDC 认证使我们能够直接进入布鲁氏菌和柯克斯体发病机制的 BSL-3 方面项目，这些项目是通过美国国立卫生研究院落基山生物防御卓越研究中心。此外，该设施的可用性使我们能够成功竞争国家补充和替代医学中心的 NIH 计划项目，该项目是一项为期五年的研究，旨在研究天然产品对减少传染病和自身免疫性疾病的影响。在以下各节中，子项目进度报告记录了 Core C 如何继续在过去的成功基础上发展并从其重组中受益。