Genetic Analysis: Psychiatric and Other Complex Diseases

遗传分析：精神疾病和其他复杂疾病

• 批准号: 8096815
• 负责人: MYRNA M WEISSMAN
• 金额: $ 20.92万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8096815
• 关键词: Complex; Disease; genetic analysis

DESCRIPTION (provided by applicant): This is a proposal to continue a successful research training program in the genetic epidemiology and statistical analysis of psychiatric and other complex diseases. The field of psychiatric genetics is changing rapidly, and successful investigators must be competent in a broad array of techniques, must be able to speak the languages of fields outside their own, and must be able to collaborate effectively with scientists in other fields. The program trains postdoctoral (M.D., Ph.D., and Dr.P.H.) and predoctoral Fellows. Training has both (a) didactic and (b) research components. (a) The didactic component is further broken down into an academic program and a series of practical laboratory rotations. The academic program includes a series of academic courses in human genetics, epidemiology, statistical genetics, computer simulations, research communication skills, and responsible conduct of research. The laboratory rotations take place in a number of laboratories at Columbia University, where a rich and broad variety of genetic studies are being carried out. (b) In the research component each Fellow works closely with a Preceptor on an independent research project of the Fellow's choosing; the Fellow prepares a clearly written research proposal, carries out the proposal, prepares an oral description of the study and its results, and prepares a publishable manuscript based on the completed study. At the end of training, Fellows understand: the biological underpinnings of genetic influences on disease risk; how to formulate testable hypotheses in human genetics and design studies to test those hypotheses; the critical importance of phenotype definition; how to design data collection strategies for genetic studies; the factors that go into selecting appropriate samples; issues of responsible conduct of research and Good Clinical Practice; the mathematical underpinnings of genetic analysis, including familial aggregation studies, twin studies, and segregation, linkage, and association analysis; laboratory techniques such as genotyping and sequencing, extracting DMA from blood, PCR, etc.; proper data management of genetic and clinical data through the use of a data base management system; how to use current genetic analysis programs, to interpret the results, and to test and evaluate new methods of genetic analysis as they become available; and microarray technology and other current molecular-biological techniques.

描述（由申请人提供）：这是一项提议，旨在继续在精神病和其他复杂疾病的遗传流行病学和统计分析方面取得成功的研究培训计划。精神病遗传学领域正在迅速变化，成功的研究人员必须在广泛的技术中能够胜任，必须能够在自己之外说的领域语言，并且必须能够与其他领域的科学家有效合作。该计划训练博士后（M.D.，Ph.D.和Dr.P.H.）和前研究者。培训具有（a）教学成分和（b）研究组件。 （a）教学成分进一步分为学术课程和一系列实践实验室轮换。该学术课程包括一系列人类遗传学，流行病学，统计遗传学，计算机模拟，研究沟通技巧以及负责任的研究的学术课程。实验室轮换发生在哥伦比亚大学的许多实验室中，在那里进行了丰富而广泛的遗传研究。 （b）在研究组成部分中，每个研究员都与同伴选择的独立研究项目密切合作；该研究员准备了一项清晰书面的研究建议，进行了提案，准备了研究及其结果的口头描述，并根据完整的研究准备了可发布的手稿。在训练结束时，研究员理解：遗传影响疾病风险的生物基础；如何在人类遗传学和设计研究中提出可检验的假设来检验这些假设；表型定义的关键重要性；如何为遗传研究设计数据收集策略；选择适当样本的因素；负责任的研究和良好临床实践的问题；遗传分析的数学基础，包括家族聚集研究，双研究和隔离，联系和关联分析；实验室技术，例如基因分型和测序，从血液，PCR等提取DMA。通过使用数据库管理系统对遗传和临床数据进行适当的数据管理；如何使用当前的遗传分析程序来解释结果，并在可用时测试和评估遗传分析的新方法；以及微阵列技术和其他当前的分子生物学技术。

项目成果

Structural equation modeling of the relationships between pesticide poisoning, depressive symptoms and safety behaviors among Colorado farm residents.

• DOI: 10.1300/j096v11n03_05
• 发表时间: 2006-01-01
• 期刊: Journal of agromedicine
• 影响因子: 2.4
• 作者: Beseler, Cheryl Lynn;Stallones, Lorann
• 通讯作者: Stallones, Lorann

APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk.

• DOI: 10.1371/journal.pone.0024669
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Geng H;Law PP;Ng MC;Li T;Liang LY;Ge TF;Wong KB;Liang C;Ma RC;So WY;Chan JC;Ho YY
• 通讯作者: Ho YY

Apolipoprotein M gene (APOM) polymorphism modifies metabolic and disease traits in type 2 diabetes.

• DOI: 10.1371/journal.pone.0017324
• 发表时间: 2011-02-24
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zhou JW;Tsui SK;Ng MC;Geng H;Li SK;So WY;Ma RC;Wang Y;Tao Q;Chen ZY;Chan JC;Ho YY
• 通讯作者: Ho YY