Racial Disparities in Liver Diseases

肝脏疾病的种族差异

基本信息

批准号：
7482271
负责人：
CHARLES D HOWELL
金额：
$ 19.43万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7482271
关键词：
AFP gene Abdomen Accounting Acute Acute Hepatitis C Address Adherence Adverse effects Adverse event African African American Aftercare Age-Years Albumins Alcohol consumption Am 80 Ancillary Study Antibodies Antiviral Agents Antiviral Therapy Antiviral resistance Behavior Bilirubin Biochemical Bioinformatics Biological Assay Biological Markers Biology Biopsy Blood Blood Urea Nitrogen Blood urea nitrogen measurement Boston CD4 Positive T Lymphocytes CD8B1 gene Calendar California Caucasians Caucasoid Race Ceruloplasmin Cessation of life Chemistry Chicago Cholesterol Chronic Chronic Hepatitis C Cirrhosis Class Clinical Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials Design Coagulation Process Collection Combined Modality Therapy Computer software Computers Contraceptive methods Contracts Creatinine Cytotoxic T-Lymphocytes DNA Microarray Chip DNA Microarray format DNA-Directed RNA Polymerase Daily Data Data Coordinating Center Date/Time Death Rate Detection Development Digestive System Disorders Disease Disease Outcome Disease Progression Doctor of Philosophy Dose Drops Drug Exposure Drug Kinetics Education Educational process of instructing Effectiveness Electrocardiogram Electronics Elements Eligibility Determination End Point Enrollment Epidemiology Ethics Etiology Event Exhibits Fasting Female Female of child bearing age Ferritin Frequencies Funding Future Gender Gene Expression Genes Genetic Genetic Transcription Genome Genomics Genotype Glucose Goals Grant HIV Health Health Care Costs Hepatic Hepatitis B Hepatitis B Surface Antigens Hepatitis C Hepatitis C virus Hepatocyte High Prevalence Hip region structure Histology Hour Human Image Immune Immune response Immune system Immunity Immunology Immunotherapy In Vitro Incidence Indiana Individual Infection Infectious Diseases Research Inflammation Informed Consent Ingestion Injection of therapeutic agent Injury Instruction Insulin Intake Integration Host Factors Interferon-alpha Interferons Interview Iron Kinetics Label Laboratories Letters Link Liver Liver Cirrhosis Liver diseases Los Angeles Lung diseases Lymphocyte Maryland Measurement Measures Medical Medical History Medical center Mentors Mentorship Metabolism Methodology Michigan Microarray Analysis Microprocessor Microscopic Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Minority Modeling Molecular Profiling Monitor National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases Nonstructural Protein North Carolina Not Hispanic or Latino Nuclear Numbers Outcome Participant Pathogenesis Pathologist Pathology Patient Care Patient Education Patient Self-Report Patients Pattern Peer Review Pegylated Interferon Alfa Peripheral Blood Mononuclear Cell Pharmaceutical Preparations Phase Phosphotransferases Pilot Projects Play Polymerase Chain Reaction Population Population Study Pregnancy Tests Prevalence Preventive Medicine Primary carcinoma of the liver cells Principal Investigator Problem Solving Procedures Production Property Protocols documentation Purpose Quality of life Questionnaires RNA RNA replication Race Rate Recording of previous events Records Relative (related person)Reporting Request for Proposals Research Research Design Research Personnel Research Project Grants Research Training Resistance Resolution Ribavirin Role Safety Sample Size Sampling San Francisco Scientist Score Screening procedure Self Efficacy Self Management Self-Administered Series Serologic tests Serum Serum Total Iron-Binding Capacity result Services Sex Functioning Side Signal Transduction Social support Specialist Specific qualifier value Staging Structure Study of serum Surveys Symptoms System T-Lymphocyte Techniques Technology Telephone Testing Thoracic Radiography Thyroid Gland Time Tissue-Specific Gene Expression Tissues Training Transaminases Treatment Efficacy Treatment Failure Treatment outcome Triglycerides United States United States Food and Drug Administration Universities Uric Acid Urinalysis Urine Variant Vial device Viral Viral Antigens Viral Drug Resistance Viral Genome Viral Load result Viral Physiology Viral load measurement Viremia Virus Virus Diseases Visit Week Weight Woman Yang alpha 1-Antitrypsin alpha-Fetoproteins anti-hepatitis C base cDNA Arrays career caucasian American child bearing cohort cytokine data mining day design drug testing efficacy evaluation enzyme linked immunospot assay follow-up gastrointestinal genetic risk factor health disparity illness length improved in vivo inclusion criteria innovation interest interferon therapy intrahepatic liver biopsy male medical schools medication compliance mortality novel nuclease patient oriented patient oriented research peginterferon alfa-2a peginterferon alfa-2b peripheral blood professor programs racial difference research study response sample collection self esteem skills social success therapy adherence therapy resistant tool touchscreen treatment duration vaccine development viral RNA virology virus genetics

项目摘要

DESCRIPTION (provided by applicant): The applicant's long-term career objective is to decrease racial disparities in liver diseases in the United States by conducting well-designed patient-oriented research and by increasing the number of highly trained research scientists engaged in patient-oriented research in digestive diseases. Chronic hepatitis C virus (HCV) infection is the most common etiology for liver cirrhosis and a major cause for primary hepatocellular carcinoma (HCC) in the US. Several well-designed population studies have found a greater HCV prevalence and both a higher HCC incidence and mortality from primary hepatocellular carcinoma in Black Americans compared to White Americans. Ironically, Blacks have a much lower rate of HCV clearance during peginterferon plus ribavirin treatment. A better understanding of the causes for health disparities based on race is a necessary to develop comprehensive strategies to improve the health of racial minorities as well as the general US populace. Dr. Howell is an established investigator with an excellent track in patient-oriented research on racial disparities. His immediate career objectives are: 1) to develop a new patient-oriented research studies investigating the basis for racial disparities in liver disease; 2) to provide high-quality mentorship for the increasing numbers of trainees interested in patient-oriented liver research at the University of Maryland, including Gastrointestinal and Infectious Diseases research training grants; and 3) to strengthen his background for future patient-oriented research projects and mentoring by completing didactic coursework in clinical investigation. The Midcareer Investigator Award in Patient-Oriented Research (K24) award will enhance the applicant's career development and future success in patient-oriented research by allowing him to decrease his patient care, teaching, and institutional service obligations and to spend more time pursuing these important goals and objectives.

描述（由申请人提供）：申请人的长期职业目标是通过开展精心设计的以患者为导向的研究以及增加从事以患者为导向的消化系统疾病研究的训练有素的研究科学家的数量来减少美国肝脏疾病的种族差异。慢性丙型肝炎病毒（HCV）感染是肝硬化最常见的病因，也是美国原发性肝细胞癌（HCC）的主要原因。几项精心设计的人群研究发现，与美国白人相比，美国黑人的丙型肝炎病毒（HCV）患病率更高，原发性肝细胞癌的肝癌发病率和死亡率也更高。具有讽刺意味的是，黑人在聚乙二醇干扰素加利巴韦林治疗期间的丙肝病毒清除率要低得多。更好地了解基于种族的健康差异的原因对于制定改善少数族裔以及美国普通民众健康的综合战略是必要的。豪厄尔博士是一位资深的研究者，在以患者为中心的种族差异研究方面有着出色的表现。他的近期职业目标是：1）开展一项新的以患者为导向的研究，调查肝病种族差异的基础； 2) 为马里兰大学越来越多对以患者为导向的肝脏研究感兴趣的学员提供高质量的指导，包括胃肠道和传染病研究培训补助金； 3) 通过完成临床研究的教学课程，加强未来以患者为导向的研究项目和指导的背景。以患者为导向的研究中的职业生涯中期研究员奖（K24）将让申请人减少患者护理、教学和机构服务的义务，并花更多的时间追求这些重要的目标，从而增强申请人的职业发展和未来在以患者为导向的研究方面的成功。目的和目标。