An Exercise Intervention to Improve Health in Postmenopausal Cancer Survivors

改善绝经后癌症幸存者健康的运动干预

基本信息

批准号：
8119394
负责人：
M. Tish K KNOBF
金额：
$ 36.13万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-11 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8119394
关键词：
Activities of Daily Living Adjuvant Therapy Aerobic Aftercare Anxiety Attenuated Biological Markers Blood Pressure Body Composition Body fat Bone Density Breast Calcium Cancer Patient Cancer Survivor Cardiovascular system Communities Control Groups Data Diabetes Mellitus Exercise Exercise stress test Fatigue Fatty acid glycerol esters Female Fitness Centers Glucose Goals Guidelines Health Health Promotion Hemoglobin Hemoglobin A Insulin Resistance Intervention Intervention Trial Joints Life Lipids Long-Term Effects Malignant Neoplasms Measures Menopause Mental Depression Metabolic Modeling Osteoporosis Outcome Outcome Study Perimenopause Personal Satisfaction Physical Function Physical activity Physiological Physiology Population Populations at Risk Postmenopause Quality of life Randomized Controlled Trials Reaction Recommendation Recruitment Activity Rectal Lymphoma Resistance Risk Risk Factors Risk Reduction Second Primary Cancers Serum Site Sleep Solid Neoplasm Stimulus Supplementation Time Vertebral column Vitamin D Weight Weight Gain Woman Writing bone bone loss bone mass cancer therapy cardiovascular disorder risk design fasting glucose fitness functional status hip bone improved intervention effect muscle form osteogenic prevent primary outcome psychologic secondary outcome social therapy design

项目摘要

DESCRIPTION (provided by applicant): The purpose of the proposed exercise intervention trial is to improve physiologic health outcomes in peri- menopausal and early postmenopausal female cancer survivors. This randomized controlled trial (RCT) will be the first to evaluate an endurance-resistance exercise intervention that targets disturbances in normal physiology related to cancer treatment and menopause. Specifically, the intervention is designed to preserve bone mass and body composition, to improve metabolic risk profile and to improve functional status. Women with solid tumors (breast, gynecological, colo-rectal) and lymphoma (N=150) who have completed definitive treatment (<3 years) and are within 5 years of menopause (induced or natural) will be recruited to participate in a 12 month RCT of an endurance-resistance exercise intervention versus a health promotion control group. The specific aims of the study are to: 1) evaluate the effect of the intervention on bone mass and body composition, 2) examine the effect of intervention on metabolic risk factors (lipids, fasting glucose, insulin resistance, Hemoglobin A1-C (Hb A-1C) and blood pressure) and 3) examine the effects of an exercise intervention on functional status. The experimental intervention is a 12 month endurance-resistance intervention, designed with ground and joint reaction forces to provide an increased osteogenic stimulus, delivered 3 times/week at a community fitness center with on-site study interventionists, supplemented by recommendations for 30 minutes of physical activity on > 2 other days. The health promotion control group will receive written recommendations for physical activity > 5 days per week. Both groups will receive dietary guidelines for cancer survivors and calcium and vitamin D supplementation. Data will be collected at baseline, 6 and 12 months. An exercise stress test, dual energy x-ray absorptiometry and serum biomarkers for bone re-modeling will provide the objective measures for the bone, body composition and functional ability and serum glucose, insulin resistance, Hemoglobin A-1C and lipids will describe the metabolic risk profile. The findings of this study will have significant implications for risk reduction in female cancer survivors.

描述（由申请人提供）：拟议的运动干预试验的目的是改善围绝经期和绝经后早期女性癌症幸存者的生理健康结果。这项随机对照试验 (RCT) 将是第一个评估耐力抗阻运动干预措施的项目，该干预措施针对与癌症治疗和更年期相关的正常生理紊乱。具体来说，干预措施旨在保持骨量和身体成分，改善代谢风险状况并改善功能状态。已完成根治性治疗（<3 年）且绝经（诱导或自然）5 年内的患有实体瘤（乳腺癌、妇科、结肠直肠癌）和淋巴瘤 (N=150) 的女性将被招募参加一项 12 项研究。耐力抗阻运动干预与健康促进对照组的月随机对照试验。该研究的具体目的是：1）评估干预对骨量和身体成分的影响，2）检查干预对代谢危险因素（血脂、空腹血糖、胰岛素抵抗、血红蛋白A1-C（Hb） A-1C) 和血压) 和 3) 检查运动干预对功能状态的影响。实验性干预是一项为期 12 个月的耐力抵抗干预，旨在利用地面和关节反作用力来提供增加的成骨刺激，每周在社区健身中心与现场研究干预人员一起进行 3 次，并辅以 30 分钟的建议其他超过 2 天进行体力活动。健康促进对照组将收到关于每周 > 5 天身体活动的书面建议。两组患者都将收到癌症幸存者的饮食指南以及钙和维生素 D 补充剂。将在基线、6 个月和 12 个月时收集数据。运动压力测试、双能 X 射线吸收测定法和用于骨重建的血清生物标志物将为骨骼、身体成分和功能能力提供客观测量，血清葡萄糖、胰岛素抵抗、血红蛋白 A-1C 和脂质将描述代谢情况风险状况。这项研究的结果将对降低女性癌症幸存者的风险产生重大影响。