Alzheimer's Disease Research Center at Columbia University

哥伦比亚大学阿尔茨海默病研究中心

• 批准号: 8141698
• 负责人: MICHAEL L SHELANSKI
• 金额: $ 6.72万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141698
• 关键词: Age; Alzheimer' s Disease; Autopsy; Award; Biological; Biology; Caring; Clinical; Clinical Research; Clinical Trials; Cognition Disorders; Cognitive; Communities; Consult; DNA; DNA Library; Data; Databases; Dementia; Developed Countries; Diagnosis; Disease; Education; Elderly; Enrollment; Environment; Ethics; Family; Gene Expression; Genetic; Genetic Variation; Genotype; Goals; Grant; Health Insurance Portability and Accountability Act; Hereditary Disease; Human; Imaging Device; Individual; Knowledge; Life; Lipids; Maintenance; Medical; Minority; Molecular and Cellular Biology; Mutation; Neurologic; Participant; Pathologic; Patients; Pharmaceutical Preparations; Physicians; Population; Prevention; Public Health; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scientist; Serum; Services; Staging; Time; Tissues; Universities; age related; brain tissue; disease natural history; improved; innovation; neuropsychological; operation; patient population; prevent; public health relevance; research study; symposium; therapy development; tool; user-friendly

DESCRIPTION (provided by applicant): The ADRC at Columbia seeks to advance and disseminate knowledge of the causes, prevention and treatment of Alzheimer's Disease and other age-related dementing disorders. To do this, we maintain and follow a multi-ethnic and multi-racial patient population of normal elderly and the elderly with cognitive disorders to establish the natural history of the disease as a function of age and of genetic makeup. In this application we propose to use a variety of neuropsychological, neurological and imaging tools to examine the earliest stages of AD and to follow these subjects throughout their lives and to compare them to other dementing diseases. A comprehensive neuropathologic examination will be performed on the deceased participants correlated with the clinical, radiological and genetic data. Tissues and DNA obtained from these subjects will be available for research on the biology and genetics of the disease. Individual research projects within the ADRC will examine various aspects of the cellular and molecular biology of AD with emphasis on lipids, on retromer function and on the relationship of GBA mutations to dementia. Patients enrolled in the ADRC will have the opportunity to participate in trials of new drugs and treatments for dementing diseases as they become available. The well-documented cognitive status of these patients makes them highly suitable for inclusion in clinical trials. The Education and Information Core of the Columbia ADRC endeavors to educate both lay and medical communities about AD, about the latest advances in research and about the care of the AD patient. The ADRC serves as a resource for scientists with Columbia as well as outside of it, encouraging new research avenues by the award of pilot grants, by providing tissues and other biological samples, by providing access to a carefully documented patient population and by numerous seminars and Clinical Pathological Correlation Conferences. The Genetics Core serves as the major organizer of family recruitment and identification across the ADRCs and ADCs as well as resources for genotyping and gene expression studies. HIPAA compliant data organization and statistical consulting services are provided under the ADRC to the research community at Columbia and external to it.

描述（由申请人提供）：哥伦比亚的ADRC试图促进和传播对阿尔茨海默氏病以及其他与年龄有关的痴呆症的原因，预防和治疗的知识。为此，我们维持并遵循正常老年人和患有认知障碍的老年人的多种族和多种族患者人群，以确立疾病的自然历史，这是年龄和基因组成的函数。在此应用中，我们建议使用各种神经心理学，神经和成像工具来检查AD的最早阶段，并在一生中遵循这些主题，并将其与其他痴呆疾病进行比较。对死者参与者将进行全面的神经病理检查，与临床，放射学和遗传数据相关。从这些受试者获得的组织和DNA将用于研究该疾病的生物学和遗传学。 ADRC中的个别研究项目将检查AD的细胞和分子生物学的各个方面，重点是脂质，缩回功能以及GBA突变与痴呆症的关系。参加ADRC的患者将有机会参与新药的试验和痴呆疾病治疗的试验。这些患者有据可查的认知状况使它们非常适合纳入临床试验。哥伦比亚ADRC的教育和信息核心努力向外行和医疗社区提供有关AD的教育，有关研究的最新进展以及广告患者的护理。 ADRC是哥伦比亚和外部科学家的资源，通过提供组织和其他生物样本，通过提供仔细记录的患者人群，以及许多研讨会和临床病理相关性会议，通过提供组织和其他生物样本来鼓励新的研究途径。遗传学核心是ADRC和ADC的家庭招募和鉴定的主要组织者，以及用于基因分型和基因表达研究的资源。 ADRC下向哥伦比亚的研究界和IT外部提供了符合HIPAA的数据组织和统计咨询服务。