Alabama Neuroscience Blueprint Core Center

阿拉巴马州神经科学蓝图核心中心

基本信息

批准号：
8138067
负责人：
Kevin A Roth
金额：
$ 104.4万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-04 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8138067
关键词：
Alabama Neuroscience Blueprint Core Center

项目摘要

Neuroscience is one of the most important areas of modern biomedical research. Despite the declaration of the 1990's as the "Decade of the Brain" and significant scientific advances over the last 15 years, effective treatments for neurological and psychiatric diseases remains the largest and fastest growing unmet medical need in the United States. To meet this need, a multi-disciplinary and integrative approach to neuroscience research is essential. Faithful small animal models of human neurological and psychiatric function and dysfunction must be developed and capitalized upon to enhance our understanding of the nervous system and to aid the development of new disease prevention and treatment strategies. The University of Alabama at Birmingham (UAB) has a long history of establishing and supporting thematic cores and centers and as part of a recently completed UAB School of Medicine Strategic Planning process, the development of a truly innovative and interdisciplinary Comprehensive Neuroscience Center has been identified as a top institutional priority. UAB has experienced a dramatic influx of accomplished neuroscience investigators in numerous departments over the last several years and has committed substantial resources to the recruitment of both junior and senior level neuroscience investigators over the next five years. In this application we propose to establish a series of inter-related core facilities that will facilitate ongoing studies of genetically modified rodents and other small animals and enhance future generation, characterization, and mechanistic analyses of small animal models of neurological and psychiatric function and dysfunction. In addition to an Administrative Core (Core A), five new research cores will be established: Core B, Molecular Engineering; Core C, Cellular and Molecular Neuropathology; Core D, Neuroimaging; Core E, In Vivo Physiology & Phenotyping; and Core F, Cellular and Synaptic Physiology. These cores are specifically designed to provide new research capabilities and will complement existing facilities to provide neuroscience investigators unparalleled ability to develop and study unique animal models of neurobiology and neuropathology. In addition to the large neuroscience community at UAB, the Alabama Neuroscience Blueprint Core Center will support the research activities of Neuroscience Blueprint funded investigators throughout the State of Alabama and at institutions in neighboring states. Combined with ongoing efforts to establish a Comprehensive Neuroscience Center at UAB, this application will dramatically enhance neuroscience research capabilities in the Deep South. Finally, a major goal of this application is to provide junior investigators and previously funded Blueprint Institute and Center neuroscientists a mechanism by which they can be scientifically productive during an exceedingly tight NIH budget period.

神经科学是现代生物医学研究中最重要的领域之一。尽管在过去15年中宣布1990年代是“大脑十年”和显着的科学进步，但在美国，神经和精神病的有效治疗仍然是美国最大，最快的未满足医疗需求。为了满足这一需求，对神经科学研究的多学科和综合方法至关重要。必须开发和利用人类神经和精神病功能和功能障碍的忠实小动物模型，以增强我们对神经系统的理解，并帮助发展新的疾病预防和治疗策略。阿拉巴马大学伯明翰大学（UAB）拥有建立和支持主题核心和中心的悠久历史，并且作为最近完成的UAB医学学院战略计划过程的一部分，已经确定了真正创新和跨学科的神经科学中心的发展作为最重要的机构优先事项。在过去的几年中，UAB在许多部门都经历了大量的神经科学调查人员的大量涌入，并在未来五年内为招募初级和高级神经科学调查人员提供了大量资源。在此应用中，我们建议建立一系列相互关联的核心设施，以促进对转基因啮齿动物和其他小动物的持续研究，并增强对神经和精神病功能和功能障碍的小动物模型的未来产生，表征和机械分析。除了行政核心（核心A）外，还将建立五个新的研究核心：核心B，分子工程；核C，细胞和分子神经病理学；核心D，神经影像学；核心E，体内生理和表型；和核F，细胞和突触生理学。这些核心是专门设计的，旨在提供新的研究能力，并将补充现有的设施，以提供神经科学研究者的无与伦比的能力来开发和研究神经生物学和神经病理学的独特动物模型。除了UAB的大型神经科学社区外，阿拉巴马州的神经科学蓝图核心中心还将支持整个阿拉巴马州和邻国机构的神经科学蓝图资助的研究活动。结合不断在UAB建立全面的神经科学中心的努力，该应用将极大地增强南方深处的神经科学研究能力。最后，该应用程序的主要目标是为初级调查人员和以前资助的蓝图研究所和中心神经科学家提供一种机制，它们可以在NIH非常紧张的NIH预算期间具有科学生产力。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

DOI：
10.1016/j.nbd.2009.10.011
发表时间：
2010-02
期刊：
Neurobiology of disease
影响因子：
6.1
作者：
Ruan Q;Harrington AJ;Caldwell KA;Caldwell GA;Standaert DG
通讯作者：
Standaert DG

Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo.

红细胞和体内血管室中血红蛋白β93半胱氨酸残基的抗氧化功能。

DOI：
10.1016/j.freeradbiomed.2012.11.003
发表时间：
2013
期刊：
Free radical biology & medicine
影响因子：
7.4
作者：
Vitturi,DarioA;Sun,Chiao-Wang;Harper,VictoriaM;Thrash-Williams,Bessy;Cantu-Medellin,Nadiezhda;Chacko,BaluK;Peng,Ning;Dai,Yanying;Wyss,JMichael;Townes,Tim;Patel,RakeshP
通讯作者：
Patel,RakeshP

Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke.

DOI：
10.1016/j.neulet.2017.09.062
发表时间：
2017-11-20
期刊：
Neuroscience letters
影响因子：
2.5
作者：
Ardelt AA;Carpenter RS;Iwuchukwu I;Zhang A;Lin W;Kosciuczuk E;Hinkson C;Rebeiz T;Reitz S;King PH
通讯作者：
King PH

Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome.