RESBIO - the Technology Resource for Polymeric Biomaterials

RESBIO - 聚合生物材料的技术资源

• 批准号: 8147916
• 负责人: Joachim B. Kohn
• 金额: $ 10万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-07 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8147916
• 关键词: Advanced Development; Arts; Biocompatible Materials; Biological Models; Cardiovascular system; Cells; Cellular biology; Clinical Trials; Computer Simulation; Data Analyses; Development; Devices; Discipline; Drug Delivery Systems; Drug Industry; Engineering; Evaluation; FDA approved; Faculty; Funding; Future; Hernia; Institutes; Institution; Investigation; Laboratories; Libraries; Mechanics; Medical; Mission; Modeling; New Jersey; Pennsylvania; Polymers; Process; Property; Regenerative Medicine; Research; Research Activity; Resources; Science; Services; Stents; System; Technology; Testing; Tissue Engineering; Tissues; Training; Universities; base; combinatorial; drug discovery; medical implant; programs; repaired; research and development; three-dimensional modeling

DESCRIPTION (provided by applicant): The Resource for Polymeric Biomaterials - RESBIO - integrates a new engineering approach to biomaterials discovery with state-of-the-art research in cell biology and computational modeling. Through this unique combination of disciplines, RESBIO contributes to a quantitative (rather than qualitative) understanding of cell-material interactions leading to the accelerated discovery of polymeric biomaterials with optimized properties for specific medical applications. RESBIO's research impacts the fields of biomaterials science, tissue engineering and regenerative medicine as well as the development of new medical implants and drug delivery systems. During its first funding period, RESBIO contributed to the development of a new hernia repair device (approved by FDA) and a new cardiovascular stent (expected to enter into clinical trials in the near future). In the next funding period, RESBIO will expand its R&D Core research program into new directions by (i) progressing from qualitative to quantitative characterization studies; (ii) advancing from 2D (flat) test systems to 3D model systems for the study of cell-material interactions; and (iii) incorporating the investigation of mechanical forces acting on cells and tissues. RESBIO will develop "technology packages" that can be disseminated to and incorporated into the research activities of other laboratories through service, training and broad dissemination efforts. Core faculty are drawn from five institutions: Rutgers, the State University of New Jersey, University of Pennsylvania, Clemson University, University of Cambridge, UK and the National Institute of Standards and Technology. Seven proposed collaborative projects, diverse service interactions, and eight strategic alignments with major national research programs will strengthen RESBIO's impact on the field of biomaterials science.

描述（由申请人提供）：聚合物生物材料的资源 - RESBIO-将生物材料发现的新工程方法与细胞生物学和计算建模方面的最新研究相结合。通过这种独特的学科组合，RESBIO有助于对细胞材料相互作用的定量（而不是定性）的理解，从而导致与特定医学应用具有优化特性的聚合物生物材料的加速发现。 RESBIO的研究影响了生物材料科学，组织工程和再生医学的领域，以及新的医疗植入物和药物输送系统的开发。在其第一个资金期间，RESBIO为开发新的疝气修复装置（由FDA批准）和新的心血管支架（有望在不久的将来进行临床试验）做出了贡献。在下一个资金期间，RESBIO将通过（i）从定性到定量表征研究中将其研发核心研究计划扩展到新的方向； （ii）从2D（FLAT）测试系统到3D模型系统，以研究细胞材料相互作用； （iii）纳入了作用在细胞和组织上的机械力的研究。 RESBIO将开发可以通过服务，培训和广泛的传播工作将可以传播到其他实验室的研究活动中的“技术软件包”。核心教师来自五个机构：罗格斯，新泽西州立大学，宾夕法尼亚大学，克莱姆森大学，英国剑桥大学和国家标准技术研究所。 提出的七个合作项目，各种服务互动以及与主要国家研究计划的八项战略一致性将增强RESBIO对生物材料科学领域的影响。