PATHWAYS TO PRE-TERM BIRTH

早产的途径

• 批准号: 7380988
• 负责人: Gillian Doreen Bryant-Greenwood
• 金额: $ 5.31万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380988
• 关键词: PATHWAYS; PRE; TERM; BIRTH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm birth is when the fetus is delivered too early, before 37 weeks gestation (normal is 40-42 weeks). This is a major cause of neonatal morbidity and death and occurs in about 12% of all pregnancies in the USA. These babies are also more prone to long term effects, like obesity, diabetes and heart disease, even into adulthood. This disproportionately affects ethnic minorities and they are therefore more likely to suffer the lifelong consequences. Native Hawaiians suffer the highest infant mortality rate, followed by the Filipino population in Hawaii. Alarming data from the March of Dimes organization shows that preterm births in Hawaii increased more than 24% between 1991 and 2001. We have identified a novel protein called Pre B Cell Colony Enhancing Factor (PBEF) which we cloned in 1998 and have continued to work on with support from the Community Foundation of Hawaii. We believe that this unusual molecule is a key player in the program which initiates preterm birth. We are close to demonstrating its role in this process and have now got the personnel in place, the unique reagents and methods available to be able to accomplish a major breakthrough. This will not only provide the clinical community with better understanding, but will allow the development of better methods of preterm labor diagnosis and thus a better chance of prevention. This application addresses one main aim which is designed to establish the mechanism of PBEF action in the fetal membranes to initiate the pathway to preterm labor. These studies will significantly increase our understanding of preterm birth and will lead to some important advances in clinically valuable approaches to its prevention.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。早产是指胎儿在妊娠 37 周（正常为 40-42 周）之前过早分娩。这是新生儿发病和死亡的主要原因，在美国，约 12% 的妊娠发生这种情况。这些婴儿也更容易受到长期影响，如肥胖、糖尿病和心脏病，甚至到成年后也是如此。这对少数族裔影响尤为严重，因此他们更有可能遭受终生的后果。夏威夷原住民的婴儿死亡率最高，其次是夏威夷的菲律宾人。来自 March of Dimes 组织的令人震惊的数据显示，1991 年至 2001 年间，夏威夷的早产率增加了 24% 以上。我们已鉴定出一种名为前 B 细胞集落增强因子 (PBEF) 的新型蛋白质，我们于 1998 年克隆了该蛋白质，并继续发挥作用在夏威夷社区基金会的支持下。我们相信这种不寻常的分子是引发早产的程序中的关键角色。我们即将展示其在这一过程中的作用，并且现在已经配备了人员、独特的试剂和方法，能够实现重大突破。这不仅可以让临床界有更好的理解，而且可以开发出更好的早产诊断方法，从而有更好的预防机会。本申请的一个主要目标是建立 PBEF 在胎膜中的作用机制，以启动早产途径。 这些研究将显着增加我们对早产的了解，并将在具有临床价值的预防方法方面取得一些重要进展。