HIV SPECIFIC IMMUNE RESPONSES AND DISEASE PROGRESSION IN PEDIATRIC HIV-1 INFECTI

儿科 HIV-1 感染者的 HIV 特异性免疫反应和疾病进展

• 批准号: 7376206
• 负责人: Hans M Spiegel
• 金额: $ 0.14万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376206
• 关键词: HIV; SPECIFIC; IMMUNE; RESPONSES; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with HIV infection display great variability in their clinical course and rate of progression to AIDS. The specific aims of this study are 1) to characterize the magnitude, breadth, and epitope specificity of HIV-specific CTL and T-helper responses in a cohort of HIV-infected pediatric subjects (ages birth to 21 years); and 2) to use new assays to gain a better understanding of the determinants of innate immunity (NK cells, NKT cells) and dendritic cells/monocytes in the control of HIV viremia in pediatric subjects. One hypothesis of this study is that in pediatric subjects who are not receiving antiretroviral therapy or who are viremic on highly active antiretroviral therapy (HAART), but are asymptomatic, correlates of effective immune control of HIV-1 can be identified. The second hypothesis is that differences in innate immune responses of asymptomatic pediatric subjects with control viremia as compared to pediatric subjects with high viral loads and clinical progression, can be identified by longitudinal comparison of functional and phenotypic markers of NK cells, NKT cells and dendritic cells/monocytes.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。感染艾滋病毒的儿童和青少年在临床病程和发展为艾滋病的速度方面表现出很大的差异。本研究的具体目的是 1) 表征 HIV 感染儿科受试者（出生至 21 岁）队列中 HIV 特异性 CTL 和 T 辅助细胞反应的程度、广度和表位特异性； 2) 使用新的检测方法更好地了解先天免疫（NK 细胞、NKT 细胞）和树突状细胞/单核细胞在儿科受试者中控制 HIV 病毒血症的决定因素。这项研究的一个假设是，在未接受抗逆转录病毒治疗或接受高效抗逆转录病毒治疗 (HAART) 后出现病毒血症但无症状的儿科受试者中，可以确定 HIV-1 有效免疫控制的相关性。第二个假设是，与具有高病毒载量和临床进展的儿科受试者相比，具有控制病毒血症的无症状儿科受试者的先天免疫反应存在差异，可以通过 NK 细胞、NKT 细胞和树突状细胞的功能和表型标记物的纵向比较来识别/单核细胞。