Traumatic Brain Injury in Latin America: Lifespan Analysis

拉丁美洲的创伤性脑损伤：寿命分析

• 批准号: 8019392
• 负责人: RANDALL M CHESNUT
• 金额: $ 5.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8019392
• 关键词: Acute; Address; American; Bolivia; Brain Diseases; Brain Injuries; Caring; Characteristics; Clinical Research; Collaborations; Developing Countries; Development; Discipline; Effectiveness; Environment; Funding; Guidelines; Injury; Latin America; Length of Stay; Literature; Longevity; Medical; Monitor; Observational Study; Outcome; Patient Care; Patients; Population; Protocols documentation; Randomized Controlled Trials; Recovery of Function; Research; Research Personnel; Research Training; Resources; Role; Structure; System; Technology; Testing; Training; Training Programs; Trauma; Traumatic Brain Injury; Treatment outcome; Variant; base; design; disability; evidence base; improved; investigator training; mortality; neuropsychological; programs; prospective; randomized trial; trauma centers

DESCRIPTION (provided by applicant): The objective of this application is to establish a network of Centers of Excellence within the Latin American Brain Injury Consortium (LABIC) that will, in collaboration with U.S. partners, conduct research and training programs about traumatic brain injury (TBI). Our specific aims are: #1: In a randomized controlled trial in 3 trauma centers in Bolivia, test the effect on outcomes of management of severe TBI guided by information from ICP monitors vs. a standard empiric protocol. #2: In a prospective, observational study in 7 trauma centers in Latin America, test the association between resource availability/medical management and outcomes for patients with severe TBI. #3: Establish a network of research centers with investigators trained and skilled in the design, conduct, and funding of research programs to address TBI and other brain disorders in Latin America. We hypothesize that: #1. Patients with severe TBI whose acute care treatment is managed using ICP monitors will have significantly lower mortality and better neuropsychological and functional recovery at 6 months post-trauma than those whose treatment is managed with the standard protocol. #2. The incorporation of ICP monitoring into the care of patients with severe TBI will minimize secondary complications and decrease length of stay in ICU. #3. The association between treatment and outcomes for patients with severe TBI identified in the randomized trial of ICP monitoring will generalize to the population in the prospective, observational, study. #4. Variations in resource availability and medical management will be significantly associated with mortality and functional recovery for patients with severe TBI, after controlling for patient and injury characteristics. In fulfilling the aims of this project, important research questions will be answered about TBI in an environment of limited resources, aspects of which will generalize to other developing countries as well as to the developed world. Sustainable capacity to conduct research about TBI in Latin America will be established. Within the structure of LABIC, a cadre of professionals will be trained in clinical research who will be equipped to carry out studies that answer questions which are relevant and important to Latin America. These studies will establish a literature base from which Latin American investigators can generate their own guidelines for the treatment of TBI.

描述（由申请人提供）：本申请的目的是在拉丁美洲脑损伤联盟（Labic）内建立一个卓越中心网络，该网络将与美国合作伙伴合作，进行有关创伤性脑损伤（TBI）的研究和培训计划。我们的具体目的是：＃1：在玻利维亚3个创伤中心的一项随机对照试验中，测试了由ICP监视器与标准经验方案的信息引导的严重TBI管理结果的影响。 ＃2：在拉丁美洲7个创伤中心的一项前瞻性观察性研究中，测试了严重TBI患者的资源可用性/医疗管理与结果之间的关联。 ＃3：建立一个研究中心网络，研究人员在研究计划，行为和资金方面培训和熟练，以解决拉丁美洲的TBI和其他脑疾病。我们假设：＃1。使用ICP监测器对急性护理治疗进行严重TBI患者的死亡率将显着降低，而在创伤后6个月时，与使用标准方案进行治疗的患者在创伤后6个月相比，神经心理学和功能恢复更好。 ＃2。将ICP监测纳入严重TBI患者的护理中，将最大程度地减少次要并发症并减少ICU住院时间。 ＃3。在ICP监测的随机试验中确定的严重TBI患者的治疗与结果之间的关联将概括为前瞻性，观察性，研究中的人群。 ＃4。控制患者和损伤特征后，资源可用性和医疗管理的变化将与严重TBI患者的死亡率和功能恢复显着相关。在满足该项目的目标时，将在有限的资源环境中回答有关TBI的重要研究问题，其各个方面将推广到其他发展中国家以及发达国家。将建立有关拉丁美洲TBI研究的可持续能力。在Labic的结构中，将在临床研究中对专业人士进行培训，他们将有能力进行回答与拉丁美洲相关且重要的问题的研究。这些研究将建立一个文献基础，拉丁美洲研究者可以从中为TBI的治疗生成自己的指南。