SERUM AND CSF DRUG LEVELS AND D2 OCCUPANCY FOR PALIPERIDONE AND RISPERIDONE

帕利哌酮和利培酮的血清和脑脊液药物水平以及 D2 占用率

• 批准号: 8172419
• 负责人: Emil CHRIS MULY
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172419
• 关键词: Adverse effects; Antipsychotic Agents; Brain; Brain region; Chronic; Computer Retrieval of Information on Scientific Projects Database; Dopamine D2 Receptor; Dose; Exhibits; Funding; Future; Grant; Institution; Measures; Methodology; Monkeys; Pharmaceutical Preparations; Research; Research Personnel; Resources; Risperidone; Serum; Source; Therapeutic Effect; United States National Institutes of Health; follow-up; gastrointestinal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the past two years we have developed methodologies for chronic gastrointestinal dosing of drugs in monkeys and studied the relationship between dose, serum level, CSF level and central D2 occupancy for two antipsychotics. We determined that risperidone's actions in the brain are almost entirely the result of its active metabolite paliperidone. Additionally, we showed that these drugs do not exhibit the same occupancy of D2 receptors in all brain regions. We plan to follow up this exciting observation in future studies to relate regional D2 occupancy to measures of therapeutic effects and side effects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在过去的两年中，我们开发了猴子中药物的慢性胃肠道剂量的方法，并研究了两种抗精神病药的剂量，血清水平，CSF水平和中央D2占用率之间的关系。 我们确定利培酮在大脑中的作用几乎完全是其活性代谢产益酮的结果。 此外，我们表明这些药物在所有大脑区域中都没有表现出D2受体的占用率相同。 我们计划在未来的研究中跟进这一令人兴奋的观察结果，以将区域D2占用率与治疗效果和副作用的度量相关联。