Administration

行政

• 批准号: 8181944
• 负责人: Lynn Hlatky
• 金额: $ 104.96万
• 依托单位: STEWARD ST. ELIZABETH'S MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181944
• 关键词: Academic Training; Appointment; Arts; Back; Background Radiation; Biological; Cancer Biology; Cancer Center; Cancer Model; Clinical; Clinical Services; Country; Databases; Development; Environment; Event; Faculty; Funding; Goals; Grant; Investments; Laboratory Research; Letters; Low Dose Radiation; Malignant Neoplasms; Medical Oncology; Medical center; Medicine; Modeling; Molecular; Program Research Project Grants; Research; Research Personnel; Research Training; Resources; Risk; Running; Schools; Solid Neoplasm; Specialized Center; System; Systems Biology; Training; United States National Aeronautics and Space Administration; anticancer research; carcinogenesis; multidisciplinary; oncology; programs; research facility; square foot

The Center of Cancer Systems Biology (CCSB) St. Elizabeth's Medical Center, Tufts Univ School of Med (TUSM), brings together diverse researchers from biological, mathematical, physical and clinical backgrounds to better understand the molecular and fissue-level events underlying cancer evolufion and development. In the three years since its founding the CCSB has matured into a well-established, deeply interactive and mulfidisciplinary cancer group which it is becoming an internafionally competifive research and training facility and research data repository in cancer systems biology Tufts CCSB has already been the recipient of two federally funded multidisciplinary Program Project Grants on carcinogenesis. Each combines mathemafical and computafional modeling with state-of the art experimental cancer biology. The first is a NASA Specialized Center of Research (NSCOR) funded to study risk of solid tumor carcinogenesis from space radiafion exposure ($10 Million; PI Dr. HIatky). The second is a DOE-funded center to study carcinogenesis risk following low-dose radiation exposure from background radiation ($7.5 million to Dr. HIatky and 1 million to Dr. Hahnfeldt for mathematical analysis of this issue). Clearly, both the PI and the Center are well-versed in running large program grants on carcinogenesis. Funding of this ICBP applicafion would provide an opportunity to connect this established CCSB with the nafional networks of ICBP-funded Centers around the country also embarking on predicfive cancer modeling and thereby contribute to the NCI directed goals of this Program. Nicolaos Madias, MD, Director of Medicine, SEMC, TUSM made deliberate strategic decisions in establishing the CCSB, recruifing Dr. HIatky as director, and the dedicafion of laboratory research space and compufing resources, as well as the subsequent expansion of her group, represents a major insfitufional investment and confinuing commitment to innovafive, cuffing edge cancer research. SEMC has backed up this research commitment with a massive expansion plan being implemented for its clinical services at the Oncology Center, involving an addifional 8,000 sq ft for Rad One and an addifional 8,000 sq ft for Medical Oncology (see support letter Dr. Madias). The breadth and depth of SEMC's commitment to this long-term strategic set of goals is clear. The confinuing strength of the intellectual, academic, and training environment is reinforced by Research faculty as well as clinical training appointments through TUSM.

癌症系统生物学中心 (CCSB) 圣伊丽莎白医学中心、塔夫茨大学医学院 （TUSM），汇集了来自生物、数学、物理和临床的不同研究人员 背景以更好地了解癌症进化背后的分子和组织水平事件 发展。 CCSB成立三年来，已发展成为一个完善、深入的组织。 互动和多学科的癌症研究小组，它正在成为一个具有国际竞争力的研究 塔夫茨大学 CCSB 癌症系统生物学培训设施和研究数据存储库已 两项联邦资助的关于致癌作用的多学科计划项目赠款的获得者。每个 将数学和计算模型与最先进的实验癌症生物学相结合。这 第一个是 NASA 专门研究中心 (NSCOR) 资助研究实体瘤致癌风险 太空辐射暴露（1000 万美元；PI Dr. HIatky）。第二个是美国能源部资助的研究中心 背景辐射低剂量辐射后的致癌风险（向 Dr. 750 万美元） HIatky 和 ​​100 万给 Hahnfeldt 博士对这个问题进行了数学分析）。显然，PI 和 该中心擅长管理有关癌症发生的大型项目资助。 ICBP 申请的资助 将提供一个机会将这个已建立的 CCSB 与 ICBP 资助的国家网络连接起来 全国各地的中心也开始开展预测癌症建模，从而为 NCI 做出贡献 本计划的直接目标。 Nicolaos Madias，医学博士，SEMC，TUSM 医学主任 建立 CCSB、聘请 HIatky 博士担任主任的战略决策以及 实验室研究空间和计算资源，以及她的团队随后的扩张， 代表着对创新、尖端癌症的重大机构投资和持续承诺 研究。 SEMC 已通过一项大规模扩展计划来支持这一研究承诺 为肿瘤中心的临床服务实施，其中 Rad One 额外占地 8,000 平方英尺 另有 8,000 平方英尺用于肿瘤内科（请参阅 Madias 博士的支持信）。广度和深度 SEMC 对这套长期战略目标的承诺是明确的。的持续强度 研究人员和临床培训加强了知识、学术和培训环境 通过TUSM 进行预约。