THE COMPARISON OF PLACENTAL AND UMBILICAL NUCLEATED RED BLOOD CELL COUNT

胎盘和脐带有核红细胞计数的比较

• 批准号: 7376109
• 负责人: Michael Glenn Ross
• 金额: $ 0.04万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376109
• 关键词: COMPARISON; PLACENTAL; UMBILICAL; NUCLEATED; RED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will attempt to quantify the presence and number of a certain type of blood cell (nucleated red blood cell; nRBC) in the placenta and umbilical cord blood. The placenta is an organ used by the mother for oxygenation and nutrition of the fetus. This organ is no longer needed by the mother or the fetus after birth and is generally discarded or sent to pathology. The umbilical cord is attached to this organ and carries blood to and from the fetus. The umbilical cord likewise is discarded after birth. This project will involve collection of the placenta and umbilical cord blood of 100 mothers who deliver at Harbor-UCLA Medical Center (HUMC). Following delivery, umbilical cord artery and vein specimens will be obtained for pH and blood gas analysis and nRBC count. Placental tissue will be examined by the HUMC Pathology Dept (Dr. L. McPhaul) for nRBC count. During the first 30 minutes of newborn life, a capillary heel stick blood sample will be obtained for pH, blood gas and nRBC. We will assess the relation of umbilical arterial blood, and newborn capillary heel blood and placental nRBC count. We will futher assess the correlation of umbilical and newborn pH and base excess values to the level of nRBC.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。该项目将尝试量化胎盘和脐带血中某种类型的血细胞（有核红细胞；nRBC）的存在和数量。胎盘是母亲为胎儿提供氧气和营养的器官。母亲或胎儿出生后不再需要该器官，通常会被丢弃或送去病理学。脐带附着在这个器官上，为胎儿输送血液。脐带同样在出生后被丢弃。该项目将收集 100 名在 Harbor-UCLA 医疗中心 (HUMC) 分娩的母亲的胎盘和脐带血。分娩后，将采集脐带动脉和静脉样本进行 pH 值和血气分析以及 nRBC 计数。胎盘组织将由 HUMC 病理学部（L. McPhaul 博士）检查 nRBC 计数。在新生儿出生后的前 30 分钟内，将采集毛细血管足跟血样本以检测 pH 值、血气和 nRBC。 我们将评估脐动脉血、新生儿毛细血管跟血和胎盘 nRBC 计数的关系。我们将进一步评估脐带和新生儿 pH 值以及碱过剩值与 nRBC 水平的相关性。