Nanoengineering Core

纳米工程核心

• 批准号: 7983113
• 负责人: MAURO FERRARI
• 金额: $ 13.55万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7983113
• 关键词: Biological; Characteristics; Chitosan; Collaborations; Complex; Core Facility; Detection; Development; Devices; Early Diagnosis; Environment; Equipment; Gold; Human Resources; International; Legal patent; Malignant neoplasm of pancreas; Methods; Molecular Profiling; Monitor; Nanotechnology; Ovarian; Particulate; Process; Production; Proteomics; Protocols documentation; Publications; Reproducibility; Research; Research Personnel; Silicon; Silicon Dioxide; Solid; Staging; Surface; System; Technology; Texas; Therapeutic; Translating; Translations; Treatment Efficacy; Universities; Validation; Work; austin; base; clinical application; design; interest; nanoengineering; nanomachine; nanoparticle; nanoshell; operation; particle; professor; tool; vector

CORE TITLE: Nanoengineering Core CORE SUMMARY: The Multi-Stage Vectors (MSV), mesoporous silicon particles, serve as an 'integrator', and vectoring function for single types and multiple-type combinations of the nanoparticles. The MSVs are present in all TCCN projects. MSVs are manufactured using photolithographic and electrochemical methods developed by the Ferrari group in a National nanotechnology core facility at the University of Texas in Austin, where Dr. Ferrari maintains a team of 12 personnel coordinated by TCCN investigator Assistant Professor Xuewu Liu. The manufacture of MSVs involves highly specialized equipment and very complex multi-step protocols. Therefore, it is necessary to establish the mesoporous silicon-producing operation ofthe TCCN as a Nanoengineering Core, directed by Dr. Ferrari, in collaboration with Dr. West for what pertains to the integration of second-stage nanoparticles in the MSVs, and Dr. Liu. In addition to the particulate systems, the Nanoengineering Core will manufacture and characterize the mesoporous silica nanochips for proteomics and peptidomlcs, which are utilized in all TCCN projects for the monitoring of therapeutic and preventative efficacy, and the identification of multi-molecular signature markers for the early detection of ovarian and pancreatic cancer. These nanochips were also developed by the Ferrari group in the National nanotechnology core facility in Austin.

核心标题：纳米工程核心 核心摘要：多级矢量（MSV），介孔硅颗粒，充当“积分器”，以及纳米颗粒的单一类型和多种类型组合的矢量化功能。 MSV 存在于所有 TCCN 项目中。 MSV 是使用 Ferrari 集团在德克萨斯大学奥斯汀分校国家纳米技术核心设施中开发的光刻和电化学方法制造的，Ferrari 博士在该设施中维持着一支由 12 人组成的团队，由 TCCN 研究员刘学武助理教授协调。 MSV 的制造涉及高度专业化的设备和非常复杂的多步骤协议。因此，有必要建立 TCCN 的介孔硅生产操作作为纳米工程核心，由 Ferrari 博士指导，与 West 博士合作，以将第二阶段纳米粒子集成到 MSV 中，并与 Dr. Ferrari 博士合作。刘.除了颗粒系统之外，纳米工程核心还将制造和表征用于蛋白质组学和肽类化合物的介孔二氧化硅纳米芯片，这些芯片在所有 TCCN 项目中用于监测治疗和预防功效，以及识别多分子特征标记物。早期发现卵巢癌和胰腺癌。这些纳米芯片也是由法拉利集团在国家赛车场开发的 位于奥斯汀的纳米技术核心设施。