Systems Biology Core

系统生物学核心

• 批准号: 7983578
• 负责人: LEROY E HOOD
• 金额: $ 5.55万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-03 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7983578
• 关键词: Affinity; Area; Back; Biological; Biological Assay; Biological Markers; Blood; Cell surface; Chemistry; Clinical Research; Computer software; Data Analyses; Data Collection; Development; Disease; Equipment; Fractionation; Generations; Heart; Human; Institution; Laboratories; Licensing; Mass Spectrum Analysis; Methods; MicroRNAs; Mission; Organ; Peptides; Private Sector; Process; Proteins; Proteome; Proteomics; Public Sector; Reagent; Research; Resources; Sampling; Science; Signal Transduction; Software Tools; Software Validation; Systems Biology; Techniques; Technology; Technology Transfer; Training; Validation; base; commercialization; instrumentation; new technology; novel; novel strategies; response; software development; therapy resistant; tool; tumor progression

Central to the NSBCC Mission is the ability to identify and quantitate candidate protein and miRNA biomarkers for the identification of blood-based biomarker panels and cell surface proteomes. Equally important is the ability to connect those biomarkers back to their associated signaling networks that control cellular and organ function, and that are disrupted by the onset and progression of cancer, and that determine responses or resistances to therapy.

NSBCC任务的核心是能够识别和定量候选蛋白和miRNA生物标志物，以鉴定基于血液的生物标志物板和细胞表面蛋白质组织。同样重要的是能够将这些生物标志物与控制细胞和器官功能的相关信号网络连接起来，并因癌症的发作和进展而破坏，并确定反应或反应或 对治疗的抗药性。