Stressful Life Events, Genetic Variants and Obesity in Chinese Adolescents

中国青少年的压力生活事件、遗传变异与肥胖

基本信息

批准号：
8068247
负责人：
Bin Xie
金额：
$ 22.43万
依托单位：
CLAREMONT GRADUATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8068247
关键词：
12 year old Adolescent Adopted Adult Anxiety Area Behavior Behavioral Behavioral Genetics Body Weight Body mass index Brain Candidate Disease Gene Cardiovascular Diseases Categories Child Childhood China Chinese People Chronic Disease Chronic stress Cities Clinical Conflict (Psychology)DRD2 gene DRD4 gene Data Data Analyses Developed Countries Developing Countries Development Diabetes Mellitus Digestive System Disorders Disease Dopamine Drug abuse Eating Economic Development Economics Elderly Energy Intake Epidemic Etiology Event Exposure to Family Funding Gender General Population Genes Genetic Genomics Genotype Grant HTR2A gene Individual Investigation Joints Kidney Diseases Knowledge Life Life Experience Link Literature Malignant Neoplasms Mental Depression Metabolic Methaqualone Morbidity - disease rate NIH Program Announcements National Institute of Diabetes and Digestive and Kidney Diseases Obesity Overweight Pathway interactions Personal Satisfaction Phenotype Physical activity Population Predisposition Prevalence Process Public Health Reporting Rewards Sampling Satiation Schools Serotonin Signal Pathway Single Nucleotide Polymorphism Social support Stress Stressful Event Suicide attempt System TNFRSF5 gene Transdisciplinary Tobacco Research Center Transportation Variant addiction base behavior influence boys depressive symptoms dopamine system energy balance experience food consumption genetic variant genome wide association study girls improved increased appetite mental development metropolitan mood regulation neurotransmission obesity risk peer population based public health relevance response uptake

项目摘要

DESCRIPTION (provided by applicant): As China undergoes rapid economic development nd sociocultural change both obesity and stress, especially academic stress and family conflicts, among Chinese adolescents have become an increasing public health problem. Chronic stress due to stressful life events or daily hassles has been linked to the etiology of obesity through involvement of dopamine and serotonin for mood regulation leading to the disruption of energy balance. A few candidate genes regulating dopamine and serotonin synthesis, release, uptake and transportation have been identified to be associated with obesity and body mass index (BMI) with mixed findings in a limited but growing body of literature. In response to the NIDDK program announcement of Secondary Analysis in Obesity, Diabetes and Digestive and Kidney Diseases (PA-09-131), we propose to conduct a secondary analysis with existing genetic and environmental data to investigate effects of stressful life events, genetic variants and their interactions on depressive symptoms, food consumption, physical activity and inactivity, and obesity in a representative sample of Chinese adolescents living in Wuhan, China. We intend to (1) delineate effects of a battery of stressful life events assessed on four domains (school, family, peer and individual) on depressive symptom experience, food consumption, physical activity and inactivity, and overweight and obesity status; (2) systematically examine the potential impacts of specific candidate genes regulating brain serotonin and dopamine systems on depressive symptoms, eating, physical activity and overweight and obesity phenotypes; (3) investigate gene X stressful events interactions on depressive symptoms, eating, physical activity and overweight and obesity phenotypes; and (4) explore other potential moderating effects of gender, family harmony and perceived availability of social support with stressful events and specific genes on depressive symptoms, eating, physical activity and overweight and obesity phenotypes. PUBLIC HEALTH RELEVANCE: As China undergoes rapid economic development and ociocultural change both obesity and stress, especially academic stress and family conflicts among Chinese adolescents have become an increasing public health problem. The proposed study will advance our knowledge of the joint and interactive effects of genes and stressful life events on obesity and related behaviors among adolescents, with important public health implications for improving the physical development and mental well-being of adolescents.

描述（由申请人提供）：随着中国经历快速的经济发展和社会文化变革，肥胖和压力，尤其是学术压力和家庭冲突，在中国青少年中，人们已经成为越来越多的公共卫生问题。由于多巴胺和5-羟色胺的参与，导致肥胖症的病因与肥胖症有关，导致情绪调节，导致肥胖症的病因与肥胖的病因有关，从而导致能量平衡的破坏。一些调节多巴胺和5-羟色胺合成，释放，摄取和运输的候选基因已被鉴定出与肥胖和体重指数（BMI）相关的，并且在有限但增长的文献中有混合发现。为了响应NIDDK计划公告肥胖，糖尿病和消化和肾脏疾病的次级分析（PA-09-131），我们建议对现有的遗传和环境数据进行二次分析，以研究压力性生命事件的影响，遗传变异以及他们在居住在中国武汉的中国青少年的代表性样本中，在抑郁症状，食物消费，体育锻炼和肥胖中的相互作用。我们打算（1）在四个领域（学校，家人，同伴和个人）评估的一系列压力性生活事件的影响（1）对抑郁症状经验，食物消费，体育锻炼和不活动以及超重和肥胖状态的影响；（2）系统地检查调节脑血清素和多巴胺系统对抑郁症状，饮食，体育锻炼以及超重和肥胖表型的特定候选基因的潜在影响；（3）研究基因X压力事件在抑郁症状，饮食，体育锻炼以及超重和肥胖表型上的相互作用；（4）探索性别，家庭和谐以及对社会支持的其他潜在调节作用，以及压力性事件和特定基因在抑郁症状，饮食，体育锻炼以及超重和肥胖表型中的特定基因。公共卫生相关性：随着中国经历快速的经济发展和肥胖症的肥胖和压力，尤其是中国青少年的学术压力和家庭冲突已成为一个日益严重的公共卫生问题。拟议的研究将促进我们对基因和压力性生活事件的关节和交互作用的了解，对青少年的肥胖和相关行为，这对改善青少年的身体发展和心理健康的重要意义。