Predictors of Adolescent Sperm Banking: Development of a Profiling and Referral T

青少年精子库的预测因素：分析和推荐 T 的开发

• 批准号: 8105409
• 负责人: James Klosky
• 金额: $ 19.48万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105409
• 关键词: Address; Adolescent; Adult; Adverse effects; Affect; Age; Anxiety; Biological Preservation; Clinical; Communication; Cryopreservation; Development; Diagnosis; Distress; Failure; Fertility; Frequencies; Health Personnel; Infertility; Intervention; Knowledge; Light; Male Adolescents; Malignant Neoplasms; Medical; Modeling; Newly Diagnosed; Outcome; Parents; Patients; Physicians; Population; Population Intervention; Predictive Factor; Provider; Psychological Factors; Religion and Spirituality; Reporting; Research Design; Risk; Risk Factors; Socioeconomic Status; Specific qualifier value; Sperm Banks; Teenagers; base; cancer diagnosis; cancer therapy; childhood cancer survivor; design; health belief; instrument; leukemia; leukemia/lymphoma; men; novel; psychologic; psychological distress; public health relevance; sperm cell; therapy design; tool

DESCRIPTION (provided by applicant): Despite the known adverse effects of specific cancer treatments on fertility, only 18-26% of at-risk adolescents and young men cryopreserve sperm prior to cancer treatment in the US. These already less than optimal rates of sperm banking are even lower among adolescents who have increased anxiety at cancer diagnosis, are lower in age and socioeconomic status, of Evangelical religious orientation, or are diagnosed with leukemia/lymphoma. It is not clear why sperm banking is underutilized, particularly in light of the high priority that survivors of childhood cancer place on fertility and the high psychological distress associated with fertility loss. Studies addressing sperm banking among adults with cancer suggest that factors such as poor physician communication and the resulting lack of fertility-risk knowledge by patients contributes to the low frequency of sperm cryopreservation. No well-designed studies have examined risk factors associated with failure to bank sperm among adolescents with cancer, a developmentally distinct population ripe for intervention. We propose to identify factors predictive of sperm banking/not sperm banking in order to design interventions for increasing fertility preservation among adolescent males newly diagnosed with cancer. Specifically, we aim to investigate psychological, demographic, developmental, parent/guardian, provider, and medical factors predictive of sperm banking outcomes among at-risk adolescents with cancer. Once these factors have been identified, we will develop a novel Profiling and Referral Tool. This instrument will ultimately serve as an intervention for both healthcare providers and adolescents through the facilitation of appropriate referrals, and tailored interventions for decreasing barriers to sperm banking. Finally, the feasibility of the Profiling and Referral tool will be evaluated based on provider and patient report. PUBLIC HEALTH RELEVANCE: Approximately 10% of adults in the US are affected by infertility-related distress. Knowledge gained from this study may prove to be useful in providing psychological interventions for this population.

描述（由申请人提供）：尽管特定的癌症治疗对生育能力有已知的不良影响，但在美国进行癌症治疗之前，只有18-26％的高危青少年和年轻人冷冻精子。在癌症诊断时增加焦虑症，年龄和社会经济地位，福音派宗教取向或被诊断为白血病/淋巴瘤的青少年，这些已经较低的精子银行率已经较低。目前尚不清楚为什么精子银行未被充分利用，特别是考虑到儿童癌症幸存者在生育能力方面的幸存者以及与生育能力丧失相关的高心理困扰。针对癌症成年人的精子银行的研究表明，诸如医师沟通不良和导致患者缺乏生育风险知识等因素有助于精子冷冻保存的低频。没有精心设计的研究研究了与癌症青少年未能银行精子相关的危险因素，这是一种发展中不同的干预人群。我们建议确定可预测精子银行/不是精子银行的因素，以设计干预措施，以增加新诊断为癌症的青少年男性生育能力。具体而言，我们旨在调查心理，人口，发展，父母/监护人，提供者和医疗因素，可预测患有癌症的青少年的精子银行成果。一旦确定了这些因素，我们将开发一种新颖的分析和推荐工具。该工具最终将通过促进适当的推荐以及量身定制的干预措施，以减少精子银行业务的障碍，以对医疗保健提供者和青少年进行干预。最后，将根据提供商和患者报告评估分析和推荐工具的可行性。 公共卫生相关性：美国约有10％的成年人受到与不育有关的困扰的影响。从这项研究中获得的知识可能证明对为该人群提供心理干预很有用。