Virus-Host Interactions in Eukaryotic Cells

真核细胞中病毒与宿主的相互作用

• 批准号: 8126226
• 负责人: Gary A. Brewer
• 金额: $ 17.34万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8126226
• 关键词: Eukaryotic Cell; virus host interaction

DESCRIPTION (provided by applicant): This proposal is for continued support of a training program in virology, with a major focus on virus-host interactions in eukaryotic cells. Nineteen faculty members will participate, all of whom are members of at least one graduate program composed of faculty at both Rutgers University (RU) and UMDNJ-Robert Wood Johnson (RWJ) Medical School: the Coordinated Graduate Program in Microbiology and Molecular Genetics of RU and UMDNJ and the Graduate Program in Molecular Genetics and Microbiology of UMDNJ-the Graduate School of Biomedical Sciences. These two programs share recruitment, admissions, curricula, and other training activities. Five predoctoral trainees are to be supported. This training program provides education in physical techniques, recombinant DNA, immunology, host and tissue trophic mechanisms, and host defense mechanisms as applied to the problem of viral infection of eukaryotic hosts. These trainees represent a group of highly trained professionals who will apply their skills to the viral infectious disease problems now confronting the United States: such as the AIDS epidemic, the entry of dengue fever into this country, and the threat of an influenza pandemic. The agents responsible for these problems (and a variety of others) are being intensively studied here, as are research techniques applicable to many other health- related areas. Extensive core facilities are available for the use of trainees. In addition to the techniques of modern biotechnology, trainees become familiar with molecular approaches to vaccine development, approaches to molecular intervention in viral life cycles, and the molecular biology of the interferons and their receptors and signal transduction mechanisms. This program recruits trainees from a large pool of outstanding applicants, including those accepted into the RWJMS MD/PhD program and those coming from an ongoing undergraduate minority biomedical careers program at UMDNJ-RWJMS. The training faculty currently supervise minority and handicapped trainees. The current application emphasizes that the 19 laboratories comprising the training grant provide a cohesive group whose members interact well together in providing training in virology and virus-host interactions. RELEVANCE (See instructions): The object of this program is to train a cadre of students who will be well positioned to meet the challenges posed by virological diseases, those known and those unanticipated, in the twenty-first century.

描述（由申请人提供）：该提案是为了继续支持病毒学培训计划，重点是真核细胞中的病毒宿主相互作用。十九位教职员工将参加，所有人都是罗格斯大学（RU）和Umdnj-Robert Wood Johnson（RWJ）医学院的至少一项由教师组成的成员科学。这两个计划共享招聘，录取，课程和其他培训活动。将支持五名托管学员。该培训计划提供了物理技术，重组DNA，免疫学，宿主和组织营养机制的教育以及用于真核宿主病毒感染问题的宿主防御机制。这些受训者代表了一群训练有素的专业人员，他们将把自己的技能运用到现在面临的美国的病毒传染病问题上：例如艾滋病流行病，登革热进入该国以及流感大流行的威胁。在这里对负责这些问题（以及其他各种问题）的代理商进行了深入研究，适用于许多其他与健康相关领域的研究技术也是如此。广泛的核心设施可用于使用学员。除了现代生物技术的技术外，学员还熟悉疫苗开发的分子方法，病毒生命周期中分子干预的方法以及干扰素及其受体和信号转导机制的分子生物学。该计划招募了大量未杰出申请人的受训者，包括接受RWJMS MD/PHD计划的受训者，以及来自UMDNJ-RWJMS正在正在进行的本科生生物医学职业计划的受训者。培训学院目前监督少数民族和残障学员。当前的应用程序强调，包括培训赠款的19个实验室提供了一个有凝聚力的群体，其成员在提供病毒学和病毒宿主相互作用的培训方面相互作用。 相关性（请参阅说明）：该计划的目的是培训一群学生的干部，这些学生将在二十一世纪被众所周知的病毒学疾病，已知和意外的那些人所带来的挑战。