MicroCT 100

显微CT 100

• 批准号: 7793129
• 负责人: DAVID H. KOHN
• 金额: $ 38.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-31 至 2011-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793129
• 关键词: Algorithms; Area; Arts; Biology; Biomedical Research; Blood Vessels; Bone Diseases; Computer software; Computers; Core Facility; Development; Disease; Engineering; Fee Schedules; Finite Element Analysis; Funding; Health; Image; Implant; Literature; Maintenance; Measures; Mechanics; Michigan; Musculoskeletal; Output; Physiological; Regenerative Medicine; Research; Research Personnel; Resolution; Sampling; Scanning; School Dentistry; Science; Specimen; Structure; System; Technology; Time; Tissue Engineering; Tissues; Tomography, Computed, Scanners; Universities; X-Ray Computed Tomography; base; bone; college; instrument; medical schools; public health relevance; reconstruction; response; Algorithms; Area; Arts; Biology; Biomedical Research; Blood Vessels; Bone Diseases; Computer software; Computers; Core Facility; Development; Disease; Engineering; Fee Schedules; Finite Element Analysis; Funding; Health; Image; Implant; Literature; Maintenance; Measures; Mechanics; Michigan; Musculoskeletal; Output; Physiological; Regenerative Medicine; Research; Research Personnel; Resolution; Sampling; Scanning; School Dentistry; Science; Specimen; Structure; System; Technology; Time; Tissue Engineering; Tissues; Tomography, Computed, Scanners; Universities; X-Ray Computed Tomography; base; bone; college; instrument; medical schools; public health relevance; reconstruction; response

DESCRIPTION (provided by applicant): This is a proposal to support the purchase of a Scanco CT100 specimen micro computed tomography scanner (<CT) that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry. This instrument will mainly support NIH-sponsored research in School of Dentistry as well in the College of Engineering, Medical School and College of Literature, Sciences and the Arts. The requested instrument will fulfill an unmet need for <CT at the University by providing increased throughput using an automatic sample changer, shorter scanning and reconstruction times, increased resolution and ability to analyze denser materials such as implants. Software will also be included to calculate detailed bone histomorphometric parameters and to conduct finite element analysis. Increased throughput of the instrument will reduce turnover times for sample analysis while increased resolution will allow analysis of structures in the micron range such as small blood vessels, bone microcracks and dentinal tubules. The University of Michigan has one of the highest concentrations of NIH-funded investigators in the areas of bone biology, tissue engineering and regenerative medicine, all of whom will greatly benefit from purchase of this instrument. Current, there is only a single specimen <CT on campus to support approximately 90 investigators. The CT100 will accelerate research output by providing a second high capacity instrument as well as allow new types of analysis that cannot presently be conducted on this campus. This proposal includes detailed plans for maintenance and oversight of the <CT facility, a financial plan with appropriate user fee schedules and significant long-term institutional support. PUBLIC HEALTH RELEVANCE: Three-dimensional micro-computed tomography (¿CT) has become a critically important standard technology in musculoskeletal and tissue engineering research. Use of this technology has greatly accelerated advances in the understanding of bone disease and the development of strategies for engineering functional tissues by providing quantitative measures of bone responses to physiologic, biologic, mechanical, pharmacologic or disease related influences. Since its introduction into biomedical research, this radiographic based tomographic technology, along with the development of computer reconstruction algorithms, has provided the capability to characterize bone structure as it had never been characterized before. As a result, ¿CT has had a significant impact on musculoskeletal health. This is a proposal to support the purchase of a Scanco CT100 specimen ¿CT system that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry and shared with other users in the Schools of Medicine, Engineering and Literature, Arts and Sciences. The requested instrument will fulfill an unmet need for ¿CT at the University by providing increased throughput, increased resolution and ability to analyze denser materials, enabling NIH-funded users to make further advances in health related research.

描述（由应用程序提供）：这是一项建议，旨在支持购买Scanco CT100标本微型计算机断层扫描仪（<ct），该扫描仪（<ct）将成为密歇根大学牙科学院成像核心设施的一部分。该乐器将主要支持NIH赞助的牙科研究研究，以及工程学院，医学院和文学学院，科学与艺术学院。请求的仪器将通过使用自动样本更换器，较短的扫描和重建时间，增加分辨率和分析较密集的材料（例如Imprans）的能力来实现大学对<ct的未满足需求。还将包括软件以计算详细的骨骼组织形态计量参数并进行有限元分析。仪器的吞吐量增加将减少流失时间以进行样本分析，同时增加。分辨率将允许在微米范围内的结构分析，例如小血管，骨微裂纹和牙齿小管。密歇根大学是NIH资助的研究人员在骨骼生物学，组织工程和再生医学领域中最高的，所有这些都将从购买该乐器中受益匪浅。当前，校园里只有一个标本<ct可以支持约90名调查人员。 CT100将通过提供第二个高容量工具以及允许在该校园无法提供的新类型的分析来加速研究输出。该提案包括维护和监督<ct设施的详细计划，具有适当用户费用时间表的财务计划以及大量的长期机构支持。 公共卫生相关性：三维微型计算机断层扫描（CT）已成为肌肉骨骼和组织工程研究中至关重要的标准技术。该技术的使用通过提供对生理，生物学，机械，药物或疾病相关影响的骨反应的定量测量，极大地加速了对骨病的理解和工程功能组织策略的发展。自从引入生物医学研究以来，这项基于射线照相的层析成像技术以及计算机重建算法的开发提供了表征骨骼结构的能力，因为它以前从未有过表征。结果，CT对肌肉骨骼健康产生了重大影响。这是一项支持购买Scanco CT100标本�CT系统的建议，该系统将成为密歇根大学牙科学院成像核心设施的一部分，并与医学，工程和文学，艺术，艺术和科学学院中的其他用户共享。所请求的工具将通过提供增加的吞吐量，增加的分辨率和分析密集材料的能力，使NIH资助的用户能够进一步进步与健康相关研究的进步，从而满足大学对CT的需求。