Request for VivaCT 75 High Speed in vivo MicroCT Scanner

索取 VivaCT 75 高速体内 MicroCT 扫描仪

• 批准号: 7793934
• 负责人: Jie Song
• 金额: $ 44.12万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-20 至 2012-05-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793934
• 关键词: 3-Dimensional; Address; Affect; Aging; Animal Model; Animals; Area; Biocompatible Materials; Bone Diseases; Bone Regeneration; Bone Resorption; Bone Tissue; Caring; Data; Defect; Degenerative polyarthritis; Diabetes Mellitus; Disease; Excision; Funding; Genetic; Goals; Growth; Healed; Health; Image; Implant; Life; Longitudinal Studies; Malignant Neoplasms; Massachusetts; Metabolic Diseases; Modeling; Mus; Orthopedics; Osteogenesis; Pathology; Phenotype; Property; Rattus; Rheumatoid Arthritis; Speed; Testing; Translational Research; Trauma; Universities; X-Ray Computed Tomography; bone; bone loss; college; healing; in vivo; instrument; medical schools; model design; novel therapeutic intervention; novel therapeutics; public health relevance; skeletal; skeletal abnormality; skeletal disorder; tumor

DESCRIPTION (provided by applicant): The goal of this proposal is to acquire funds to purchase a Scanco VivaCT 75 high speed in vivo micro- computed tomography (<CT) instrument for 3-dimensional imaging and quantitative analyses of trabecular and cortical bone properties in longitudinal studies using small animal (mouse and rat) models. There is no similar instrument available on the University of Massachusetts Medical School (UMMS) campus or in any of the colleges and universities in the Worcester, central Massachusetts area. This in vivo <CT scanner is to be shared among 8 users for the assessment of skeletal abnormalities in genetic mouse or rat models, design and characterization of new biomaterial implants for expedited bone repair, and addressing novel therapeutic approaches for osteoarthritis, rheumatoid arthritis, and metastatic bone diseases. These on-going studies can significantly benefit from the instrument's capability to carry out longitudinal characterization of bone tissue and quantitation of multiple parameters that reflect bone formation and resorption in live small animals. The long- term growth of translational research at UMMS in the areas of cancer, aging, diabetes, and orthopedic care where the testing of the skeletal complications associated with these diseases in small animal models can be stimulated with the non-invasive in vivo <CT imaging capability. PUBLIC HEALTH RELEVANCE: The requested Scanco VivaCT 75 high-speed in vivo micro-computed tomography (¿CT) instrument will provide the means to generate quantitative data that is necessary for evaluating bone phenotypes, bone pathologies and novel therapeutic strategies to inhibit bone resorption and stimulate bone formation. This instrument will contribute to the treatment of skeletal disorders in a number of major areas of health concern: 1) hard-to-heal skeletal defects due to trauma, aging, metabolic diseases and tumor resection; 2) the debilitating metastatic diseases of bone; and 3) bone loss in osteoarthritis and rheumatoid arthritis that affects millions of people worldwide.

描述（由应用程序提供）：该提案的目的是获取资金以购买Scanco Vivact 75在体内微型计算机中（<ct）仪器中，用于使用小动物（小鼠和小鼠）模型的长态研究中的小径和皮质骨特性的三维成像和定量分析。马萨诸塞大学医学院（UMMS）校园或马萨诸塞州中部地区的任何学院和大学都没有类似的工具。该体内扫描仪应在8位用户中共享，以评估遗传小鼠或大鼠模型中骨骼异常，设计和表征加快骨修复的新生物材料侵略性，并针对骨关节炎，类风湿性关节炎和转移性骨骼疾病的新型治疗方法。这些正在进行的研究可以从仪器的能力中显着受益于对骨组织进行纵向表征的能力以及反映活小动物中骨形成和分辨率的多个参数的定量。在癌症，衰老，糖尿病和骨科护理领域的UMMS转化研究的长期增长，其中与这些疾病相关的小动物模型中与这些疾病相关的骨骼并发症的测试可以通过非侵入性的体内<ct成像能力来刺激。 公共卫生相关性：所需的Scanco Vivact 75高速体内微型扫描仪（`ct）仪器将提供能够生成定量数据的方法，这些数据是评估骨骼表型，骨骼病理和新型治疗策略所必需的定量数据，以抑制骨骼分辨率和刺激骨骼的骨骼形成。该仪器将有助于在许多主要领域的主要领域治疗骨骼疾病：1）由于创伤，衰老，代谢性疾病和肿瘤切除而引起的难以控制的骨骼缺陷； 2）骨骼的使人衰弱的转移性疾病； 3）骨关节炎和类风湿关节炎的骨质流失，影响了全世界数百万的人。