Acquisition of a Zeiss LSM710 Confocal Microscope

购买蔡司 LSM710 共焦显微镜

• 批准号: 7792780
• 负责人: MELINDA K DUNCAN
• 金额: $ 49.44万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792780
• 关键词: Animals; Arthritis; Biological Sciences; Biomedical Research; Cataract; Cells; Communities; Consult; Contract Services; Core Facility; Delaware; Development; Disease; Engineering; Ensure; Equipment; Foundations; Funding; Housing; Image; Imaging Device; Imaging Techniques; Life; Longevity; Maintenance; Malignant Neoplasms; Manufacturer Name; Microscope; Noise; Osteoporosis; Prosthesis; Request for Applications; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Resources; Schedule; Schools; Spectrum Analysis; Thrombosis; Tissue Engineering; Tissues; Training; United States National Institutes of Health; Universities; Work; angiogenesis; animal facility; instrument; meetings; repaired; tissue culture; Animals; Arthritis; Biological Sciences; Biomedical Research; Cataract; Cells; Communities; Consult; Contract Services; Core Facility; Delaware; Development; Disease; Engineering; Ensure; Equipment; Foundations; Funding; Housing; Image; Imaging Device; Imaging Techniques; Life; Longevity; Maintenance; Malignant Neoplasms; Manufacturer Name; Microscope; Noise; Osteoporosis; Prosthesis; Request for Applications; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Resources; Schedule; Schools; Spectrum Analysis; Thrombosis; Tissue Engineering; Tissues; Training; United States National Institutes of Health; Universities; Work; angiogenesis; animal facility; instrument; meetings; repaired; tissue culture

DESCRIPTION (provided by applicant): The University of Delaware (UD) is classified as a "very high research activity research university" by the Carnegie Foundation. Much of this research activity focuses on diverse fields of biomedical research, particularly in the Department of Biological Sciences and the School of Engineering and relies heavily on advanced tools for the imaging of both tissues and cells. In order to maximize the utilization of these critical instruments, UD established a multi-user imaging core facility which is responsible for equipment scheduling and maintenance, the training of users and advanced technical consulting to develop new imaging techniques. One of the first instruments acquired by this facility (over a decade ago) was a LSM510 confocal microscope which is housed in the Department of Biological Sciences due to the proximity of its major users, tissue culture facilities and the UD animal facility. This instrument is heavily used by investigators across UD, however, it is reaching the end of its lifespan and its manufacturer will no longer provide service contracts and guarantee availability of the full range of parts for its maintenance after summer 2009. This application requests funds to replace this obsolete instrument which no longer meets the full needs of our user community with an upright LSM710 confocal microscope which will be located in the microscope suite in the Department of Biological Sciences and administered by the UD core imaging facility staff. This will ensure access to a working confocal microscope on the UD main campus to all investigators who utilize the UD core imaging facility. This is a critical resource for numerous NIH funded research projects at UD investigating diverse diseases including cataracts, osteoporosis, arthritis, cancer, angiogenesis and thrombosis and will also contribute to the development of tissue prostheses to repair or replace damaged tissues. Furthermore, this microscope will enhance the biomedical research capabilities at UD since it has capabilities absent from the prior microscope including increased sensitivity, the ability to clearly image low magnification images at high pixel resolution, the ability to perform raster image correlation spectroscopy at high sensitivity and low noise, and as our only confocal with an upright configuration will be ideal to meet our growing needs to conduct fluorescent imaging of whole animals, dissected tissues and engineered living tissue prostheses.

描述（由申请人提供）：特拉华大学（UD）被卡内基基金会归类为“非常高的研究活动研究”。 这项研究活动的大部分都集中在生物医学研究的各种领域，尤其是在生物科学系和工程学院，并且很大程度上依赖于先进的工具来对组织和细胞进行成像。 为了最大程度地利用这些关键仪器，UD建立了多用户成像核心设施，该设施负责设备调度和维护，用户培训和高级技术咨询以开发新的成像技术。 该设施（十年前）获得的第一批工具之一是LSM510共聚焦显微镜，由于其主要用户，组织培养设施和UD动物设施的距离靠近生物科学系。 This instrument is heavily used by investigators across UD, however, it is reaching the end of its lifespan and its manufacturer will no longer provide service contracts and guarantee availability of the full range of parts for its maintenance after summer 2009. This application requests funds to replace this obsolete instrument which no longer meets the full needs of our user community with an upright LSM710 confocal microscope which will be located in the microscope suite in the Department of Biological Sciences and由UD核心成像设施人员管理。 这将确保向所有利用UD核心成像设施的调查人员使用UD主校园上的工作共聚焦显微镜。 对于UD研究的众多研究项目，这是研究各种疾病，包括白内障，骨质疏松症，关节炎，癌症，血管生成和血栓形成，也将有助于修复或替换受损组织的组织。 Furthermore, this microscope will enhance the biomedical research capabilities at UD since it has capabilities absent from the prior microscope including increased sensitivity, the ability to clearly image low magnification images at high pixel resolution, the ability to perform raster image correlation spectroscopy at high sensitivity and low noise, and as our only confocal with an upright configuration will be ideal to meet our growing needs to conduct fluorescent imaging of whole animals, dissected组织和设计的活组织假体。