PBeam: Fast and Easy Monte Carlo System for Proton Therapy

PBeam：用于质子治疗的快速简便的蒙特卡罗系统

基本信息

批准号：
8074574
负责人：
HARALD PAGANETTI
金额：
$ 43.22万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8074574
关键词：
Address Adopted Automobile Driving Canada Charge Climate Clinic Clinical Clinical Research Collaborations Collimator Computer software Data Data Display Development Dose Electrons Floods Funding Head Health Hot Spot Image Imaging Device Individual Knowledge Mainstreaming Malignant Neoplasms Measurement Methods National Research Council Neutrons Operating System Output Patients Protons Public Domains Radiation therapy Recording of previous events Research Research Personnel Research Project Grants Running Simulate Speed System Techniques Technology Therapeutic Therapeutic Studies Time Training Translating United States National Institutes of Health Validation Work clinical application clinical practice conventional therapy cost design detector effective therapy experience flexibility graphical user interface improved innovation new technology particle programs proton beam simulation tool treatment planning

项目摘要

DESCRIPTION (provided by applicant): Proton therapy is one of the best methods available for treating cancer. While the value of Monte Carlo (MC) simulation for proton therapy is well established, there exists no software that combines ease-of-use with the level of flexibility needed for demanding clinical and research applications. The release of the BEAM/DOSXYZ MC in 1995 effectively addressed a similar barrier for conventional therapy, releasing a flood of valuable research projects and clinical applications, but this application does not work for proton therapy. A fast, easy-to-use "BEAM/DOSXYZ for Protons" or "PBeam" will unlock great potential for MC in proton therapy. It will enable researchers and clinical physicists to accurately determine dosimetric and radiobiological aspects of proton beams for individual patients, accelerate design of new proton treatment planning and delivery systems, facilitate design of detectors for dose measurement and imaging devices for image- guided radiotherapy, and provide clinicians with the capability to exploit the power of MC simulation in clinical practice, including the creation of treatment plans for individual patients with the accuracy and functionality required to optimize treatment. We will provide PBeam free of charge, for all common operating systems, with online training materials, minimizing barriers to use. PUBLIC HEALTH RELEVANCE: While the value of Monte Carlo simulation for proton therapy is well established, there exists no software for this purpose that combines ease-of-use with the level of flexibility needed for demanding clinical and research applications. Consequently, this valuable calculation technique remains underutilized, difficult to apply and restricted to use by highly experienced software experts. With today's climate of increasing numbers of proton facilities and proton-related research, a fast and easy-to-use "PBeam" will unlock great potential for Monte Carlo in proton therapy, helping researchers study dosimetric and radiobiological aspects of proton beams, helping them improve proton delivery, treatment planning and validation and helping clinicians exploit the power of Monte Carlo simulation in routine clinical practice.

描述（由申请人提供）：质子疗法是治疗癌症的最佳方法之一。虽然蒙特卡罗 (MC) 模拟对于质子治疗的价值已得到充分证实，但目前还没有一种软件能够将易用性与要求苛刻的临床和研究应用所需的灵活性相结合。 1995 年 BEAM/DOSXYZ MC 的发布有效地解决了传统治疗的类似障碍，释放了大量有价值的研究项目和临床应用，但该应用不适用于质子治疗。快速、易于使用的“BEAM/DOSXYZ for Protons”或“PBeam”将释放 MC 在质子治疗中的巨大潜力。它将使研究人员和临床物理学家能够准确确定个体患者质子束的剂量测定和放射生物学方面，加速新质子治疗计划和输送系统的设计，促进用于图像引导放射治疗的剂量测量探测器和成像设备的设计，并提供临床医生能够在临床实践中利用 MC 模拟的力量，包括为个体患者制定具有优化治疗所需的准确性和功能的治疗计划。我们将免费提供适用于所有常见操作系统的 PBeam 以及在线培训材料，最大限度地减少使用障碍。公共健康相关性：虽然蒙特卡罗模拟对于质子治疗的价值已得到充分证实，但目前还没有用于此目的的软件能够将易用性与要求严格的临床和研究应用所需的灵活性相结合。因此，这种有价值的计算技术仍未得到充分利用，难以应用，并且仅限于经验丰富的软件专家使用。随着当今质子设施和质子相关研究数量不断增加，快速且易于使用的“PBeam”将释放蒙特卡罗在质子治疗方面的巨大潜力，帮助研究人员研究质子束的剂量学和放射生物学方面，帮助他们改善质子输送、治疗计划和验证，并帮助临床医生在常规临床实践中利用蒙特卡罗模拟的力量。