TESTING GHRELIN AND PYY VACCINES

测试 ghrelin 和 pyy 疫苗

• 批准号: 7349543
• 负责人: VICTOR A RASO
• 金额: $ 3.5万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349543
• 关键词: TESTING; GHRELIN; PYY; VACCINES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ghrelin is a modified peptide that appears to elicit a hunger response in animals. We have synthesized two ghrelin-based vaccines that have elicited specific antibody responses in mice without any harmful effects. We have also produced anti-ghrelin monoclonal antibodies from these animals. A vaccine directed against ghrelin has potential for controlling appetite and therefore could provide a beneficial treatment for obesity in humans. Therefore it is important to discover if these vaccines will elicit an immune response in non-human primates. PYY3-36 is a peptide that suppresses the hunger response in animals. We will synthesize a PYY-based vaccine and test it to see if it will elicit a specific antibody responses in mice without any harmful effects. We will also produce anti-PYY monoclonal antibodies from these animals. A vaccine directed against PYY has potential for controlling appetite and therefore could provide a beneficial treatment for anorexia or poor appetite in humans. Therefore it is important to discover if this vaccine will elicit an immune response in non-human primates.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。生长素释放肽是一种修饰肽，似乎能引起动物的饥饿反应。我们合成了两种基于生长素释放肽的疫苗，它们在小鼠体内引发了特异性抗体反应，且没有任何有害影响。我们还从这些动物中生产了抗生长素释放肽单克隆抗体。针对生长素释放肽的疫苗具有控制食欲的潜力，因此可以为人类肥胖症提供有益的治疗。因此，了解这些疫苗是否会在非人类灵长类动物中引起免疫反应非常重要。 PYY3-36 是一种抑制动物饥饿反应的肽。我们将合成一种基于 PYY 的疫苗并对其进行测试，看看它是否会在小鼠体内引发特异性抗体反应，而不会产生任何有害影响。我们还将从这些动物中生产抗 PYY 单克隆抗体。针对 PYY 的疫苗具有控制食欲的潜力，因此可以为人类厌食症或食欲不振提供有益的治疗。因此，了解这种疫苗是否会在非人类灵长类动物中引起免疫反应非常重要。