Age-Related Eye Disease Follow-up Study (AREDS) Follow-up Study

年龄相关眼病随访研究（AREDS）随访研究

• 批准号: 7968439
• 负责人: EMILY Y CHEW
• 金额: $ 3.06万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7968439
• 关键词: Adverse effects; Age; Age related macular degeneration; Antioxidants; Ascorbic Acid; Beta Carotene; Blindness; Blood specimen; Case Study; Cataract; Categories; Classification; Clinical; Clinical Trials; Copper; Data; Development; Disease; Disease Progression; Documentation; Dose; Elderly; Enrollment; Event; Eye diseases; Follow-Up Studies; Fundus; Individual; Knowledge; Literature; Natural History; Nutritional; Ophthalmic examination and evaluation; Participant; Persons; Population; Protocols documentation; Publishing; Reporting; Risk; Risk Factors; Telephone; Visit; Visual Acuity; Vitamins; Zinc; age related; base; cohort; design; follow-up; lens; outcome forecast; population based

One-hundred and five participants previously enrolled at the Clinical Center for AREDS will be followed on an annual basis for five years. These annual visits will include a comprehensive eye exam, fundus and lens photographs and a blood sample. In addition, clinical coordinators will conduct semi-annual phone calls to the participants. These follow-up visits will provide data on a cohort of participants for whom we will have the very unusual ability to report on the 15-18 year natural history of two diseases, cataract and AMD. It will also provide additional data on possible adverse effects associated with the treatment with AREDS supplements (high doses of vitamins C, E, beta-carotene, zinc and copper). There are individual case reports in the literature on the progression of AMD over a 15-year period, and population data on follow-up of cohorts of participants for 10 years, but to our knowledge no systematic data have been collected over a 15-year period. The population based data demonstrate a clear increase in the risk of AMD progression after age 80. The ability to follow this progression of disease over a very long period with serial photos will allow us to better develop hypotheses as to why some persons progress while others do not. Study Objectives The objective of this study is to follow 105 former AREDS participants annually for 5 years with a semi-annual telephone contact to collect additional data on AMD and cataracts. These follow-up visits will allow the NEI to collect additional data on possible ocular events for both AMD and cataracts and for documentation of any adverse effects associated with the AREDS treatment. Most importantly, this very long follow-up with careful photographic documentation of the progress of both cataract and AMD will allow for the development of hypotheses as to why some persons progress while others do not.

以前一百五名参与者以前在AREDS临床中心入学五年。 这些年度访问将包括全面的眼科检查，眼底和镜头照片以及血液样本。此外，临床协调员将向参与者进行半年度电话。这些后续访问将提供有关参与者队列的数据，我们将为他们提供非常不寻常的能力，以报告两种疾病的15-18年自然病史，分别是白内障和AMD。 它还将提供有关与AREDS补充剂（高剂量的维生素C，E，β-胡萝卜素，锌和铜）相关的不良影响的其他数据。 文献中有关于AMD在15年内进展的单独案例报告，并且有关参与者队列的随访10年的人口数据，但据我们所知，没有在15年内收集系统的数据。基于人群的数据表明，在80岁以后，AMD进展的风险明显增加。长期以来，使用串行照片遵循这种疾病进展的能力将使我们能够更好地提出假设，以了解为什么有些人会进步而另一些人则没有发展。 研究目标 这项研究的目的是通过半年度电话联系每年跟踪105名前AREDS参与者，以收集有关AMD和白内障的其他数据。这些后续访问将使NEI可以收集有关AMD和白内障的可能的眼事件的其他数据，并记录与AREDS治疗相关的任何不良影响。 最重要的是，这一很长的随访以及仔细的摄影文档，了解白内障和AMD的进步，将允许发展假设，以了解为什么有些人会进步而另一些人不进步。