Control of Repetitive Movement in Parkinson's Disease

控制帕金森病的重复运动

• 批准号: 7413271
• 负责人: COLUM D MACKINNON
• 金额: $ 32.81万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-25 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7413271
• 关键词: Affect; Area; Basal Ganglia; Bradykinesia; Brain; Clinical; Cues; Deep Brain Stimulation; Depth; Deterioration; Disease Progression; Disruption; Distal; Dyskinetic syndrome; Electrodes; Electroencephalography; Fingers; Fire - disasters; Frequencies; Functional disorder; Globus Pallidus; Goals; Human; Impairment; Implant; Implanted Electrodes; Individual; Levodopa; Measures; Metabolic; Methods; Motor; Motor Cortex; Movement; Movement Disorders; Neurons; Output; Parkinson Disease; Pathway interactions; Patients; Pattern; Performance; Pharmaceutical Preparations; Population; Production; Public Health; Purpose; Quality of life; Rehabilitation therapy; Research Personnel; Resolution; Role; Scalp structure; Secondary to; Severities; Structure; Structure of subthalamic nucleus; Surface; Symptoms; Techniques; Testing; Therapeutic; Time; United States; Upper Extremity; Work; awake; base; density; design; frontal lobe; impression; improved; nervous system disorder; neurophysiology; programs; research study

Parkinson's disease (PD) affects more than a million people in the United States. Voluntary movement in these patients is characterized by slowness and reduced movement amplitude (bradykinesia) and a lack of spontaneous volitional movement (akinesia). The severity of bradykinesia increases with disease progression and has a significant impact on quality of life. Bradykinesia is most evident during the performance of fast repetitive movements and worsened when external cues are removed. The purpose of this project is to examine the mechanisms contributing to impaired repetitive movement in patients with PD and the effects of the two most successful treatments for PD, levodopa and high frequency stimulation of the subthalamic nucleus (STN-DBS), on these mechanisms. The first specific aim will examine the effects of movement cueing (external vs. internal cues), frequency (0.8 Hz vs. 2 Hz) and levodopa on repetitive finger movement and movement-related cortical oscillations recorded using electroencephalography (EEC). The second specific aim will examine the effects of the same factors (cueing, movement frequency and levodopa) on the patterns of movement-related activity in the basal ganglia (a group of deep brain structures) of awake patients with PD. Basal ganglia activity will be recorded from electrodes implanted in the subthalamic nucleus (STN) of patients with PD. The third specific aim will compare the effects of levodopa versus STN-DBS on movement-related cortical oscillations. High-resolution EEC recordings of motor cortical activity will be used to examine how these treatments affect repetitive movement. These experiments will be the first to examine the neurophysiological basis for the deterioration of motor performance during repetitive movements in PD and the cortical mechanisms by which levodopa and STN-DBS improve the performance of these movements. The long-term goals of this project are twofold: to develop improved rehabilitation techniques that take advantage of factors that facilitate movement performance and to develop improved methods for the delivery of deep brain stimulation. Dysfunction of the basal ganglia is implicated in a variety of neurological disorders, including PD, that affect a large segment of the US population. This project is relevant to public health because the findings will provide a better understanding of the human basal ganglia and its role in the production of disordered movement and help to develop improved treatments.

帕金森病 (PD) 在美国影响着超过一百万人。自愿运动 这些患者的特点是动作缓慢、运动幅度减小（运动迟缓）以及缺乏 自发意志运动（运动不能）。运动迟缓的严重程度随着疾病的增加而增加 进展并对生活质量产生重大影响。运动迟缓在以下期间最为明显 快速重复运动的表现，并且当外部线索被移除时，表现会恶化。目的 该项目旨在研究导致帕金森病患者重复运动受损的机制 以及两种最成功的 PD 治疗方法——左旋多巴和高频刺激的效果 丘脑底核（STN-DBS），关于这些机制。第一个具体目标将检查以下措施的影响： 重复手指上的运动提示（外部与内部提示）、频率（0.8 Hz 与 2 Hz）和左旋多巴 使用脑电图（EEC）记录运动和运动相关的皮质振荡。这 第二个具体目标将检查相同因素（提示、运动频率和 左旋多巴）对基底神经节（一组深层大脑结构）运动相关活动模式的影响 清醒的 PD 患者。基底神经节的活动将通过植入的电极记录 PD 患者的丘脑底核 (STN)。第三个具体目标将比较左旋多巴的效果 与 STN-DBS 在运动相关皮层振荡上的比较。运动皮质的高分辨率 EEC 记录 活动将用于检查这些治疗如何影响重复运动。这些实验将 第一个研究重复性运动期间运动表现恶化的神经生理学基础 PD 中的运动以及左旋多巴和 STN-DBS 改善表现的皮质机制 这些运动。该项目的长期目标有两个：开发改进的康复服务 利用促进运动表现的因素并开发改进的技术 提供深部脑刺激的方法。基底神经节功能障碍与多种疾病有关 影响美国很大一部分人口的神经系统疾病，包括帕金森病。这个项目是 与公共卫生相关，因为研究结果将有助于更好地了解人类基底神经节 及其在运动障碍产生中的作用，并有助于开发改进的治疗方法。