Population based studies

基于人群的研究

• 批准号: 7966214
• 负责人: Carl Ola Landgren
• 金额: $ 8.1万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7966214
• 关键词: Affect; Biological; Chronic Lymphocytic Leukemia; Development; Disease; Early treatment; Enrollment; Future; Goals; Individual; Intervention; Knowledge; Modeling; Monoclonal gammopathy of uncertain significance; Multiple Myeloma; Patients; Process; Sampling; Science; base; drug development; high risk; improved; mouse model; novel; population based; prospective; treatment trial; tumor; tumor progression

During 2004-2008, I have primarily been using population-based approaches and assessed stored samples in exisiting large biobanks. From the beginning of 2009, I have started to develop novel treatment trials for myeloma patients and also I am in the process of developing new prospective patient studies for individuals affected with high-risk precursor disease. During early 2010, I predict that we will be able to enroll our first precursor patients for early intervention using targeted therapies. These studies will be based on rigorous correlative science aimed to better understand underlying biological mechanisms of tumor development. By taking these approaches, and by constantly developing and improving our concepts, I bevieve that we will be able to delay progression and ultimately cure patients from myeloma in the future. In parallel, we are in the process of developing a myeloma mouse model. The aim of this effort is to develop a model for drug development and better understanding of disease mechanisms.

在2004 - 2008年期间，我主要使用基于人群的方法并评估了储存的样品，以驱散大型生物库。 From the beginning of 2009, I have started to develop novel treatment trials for myeloma patients and also I am in the process of developing new prospective patient studies for individuals affected with high-risk precursor disease. 在2010年初，我预测，我们将能够使用靶向疗法来招募第一批前体患者进行早期干预。 These studies will be based on rigorous correlative science aimed to better understand underlying biological mechanisms of tumor development. By taking these approaches, and by constantly developing and improving our concepts, I bevieve that we will be able to delay progression and ultimately cure patients from myeloma in the future.同时，我们正在开发骨髓瘤小鼠模型。这项工作的目的是开发一种用于药物开发的模型，并更好地了解疾病机制。