Cancer Genetic Markers of Susceptibility

癌症易感性遗传标记

• 批准号: 7966689
• 负责人: Robert Hoover
• 金额: $ 39.85万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7966689
• 关键词: Brain Neoplasms; Breast; Carcinogenesis Mechanism; Cessation of life; Colorectal Cancer; Early Diagnosis; Endometrial Carcinoma; Genes; Genetic Markers; Genetic Research; Genomics; Goals; Human Genetics; Human Genome; Inherited; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Non-Hodgkin' s Lymphoma; Predisposition; Prevention; Renal carcinoma; Research Personnel; Single Nucleotide Polymorphism; Susceptibility Gene; Technology; Variant; Work; cancer genetics; cancer risk; cancer therapy; gene environment interaction; genome wide association study; insight; malignant breast neoplasm; meetings; new technology; novel strategies; tool

To help meet the Challenge Goal of eliminating suffering and death from cancer by 2015, the NCI must capitalize on the extraordinary momentum generated by advances in human genetic research. The sequencing of the human genome and the annotation of common variations, together with new technologies for analyzing single nucleotide polymorphisms (SNPs), have provided the tools for investigators to actively search for inherited variants in genes that can increase or modify cancer risk. The C-GEMS proposal will use the latest genomic technologies to perform dense whole genome scans to identify and validate susceptibility genes in the induction and progression of breast and prostate cancer, and clarify gene-gene and gene-environment interactions. This work will provide new insights into mechanisms of carcinogenesis, and point the way to novel strategies for meeting the 2015 Challenge Goal by accelerating the prevention, early detection, and treatment of cancer. Prostate cancer, lung cancer, bladder cancer, breast cancer, colorectal cancer, kidney cancer, non-Hodgkin's lymphoma (NHL), ovarian cancer, brain tumors, and endometrial cancer are the main focus of current and planned replication studies.

为了帮助实现到 2015 年消除癌症痛苦和死亡的挑战目标，NCI 必须利用人类基因研究进步所产生的非凡动力。人类基因组测序和常见变异的注释，以及分析单核苷酸多态性 (SNP) 的新技术，为研究人员提供了积极寻找可增加或改变癌症风险的基因遗传变异的工具。 C-GEMS提案将利用最新的基因组技术进行密集的全基因组扫描，以识别和验证乳腺癌和前列腺癌诱导和进展中的易感基因，并阐明基因与基因以及基因与环境的相互作用。这项工作将为致癌机制提供新的见解，并为通过加速癌症的预防、早期检测和治疗来实现 2015 年挑战目标的新策略指明道路。前列腺癌、肺癌、膀胱癌、乳腺癌、结直肠癌、肾癌、非霍奇金淋巴瘤（NHL）、卵巢癌、脑肿瘤和子宫内膜癌是当前和计划复制研究的主要焦点。