Gene Regulation

基因调控

• 批准号: 7944547
• 负责人: Stephen T Smale
• 金额: $ 6.08万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-02 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944547
• 关键词: Affect; Animal Model; Area; Cancer Center Support Grant; Cell Differentiation process; Development; Diagnosis; Fostering; Funding; Gene Expression Regulation; Gifts; Goals; Grant; Inflammation; Investments; Jonsson Comprehensive Cancer Center of University of California Los Angeles; Journals; Knowledge; Leadership; Letters; Malignant Neoplasms; Mammalian Cell; Mediating; Methodology; Molecular; National Cancer Institute; Peer Review; Physiological Processes; Process; Publications; Regulation; Research; Research Personnel; Resource Sharing; Resources; Science; Seeds; Series; Translations; Virus Latency; cancer initiation; cancer therapy; clinical application; college; cost; expectation; insight; interest; meetings; member; novel strategies; professor; programs; therapy development

The Gene Regulation Program Area is composed of 21 members, spanning 8 Departments within UCLA. In ;he past competing cycle, investigators from this Program authored 374 publications, of which 94 (25%) were nter-programmatic and 15 (4%) intra-programmatic. 155 (41%) were placed in high-impact journals. 15 members of this Program Area used 8 out of the 8 Shared Resources that are currently funded by the JCCC. During the current funding year, peer-reviewed funding totaled $12.2 million in total costs, including $1.6 million from the National Cancer Institute. As with other Program Areas, JCCC fosters a number of interactive activities and many of the Shared Resources that support investigators in the GR Program Area. During the current grant cycle, funds from the JCCC in the form of CCSG Developmental Funds, institutional support and philanthropic gifts to the GR Program Area total $832,185. These funds supported Interdisciplinary Grants, Seed Grants, recruitment/retention, Program Area Leadership support, funding for the use of emerging Shared Resources and trainees. Twelve of the Program Area Members were the recipients of JCCC support. The Gene Regulation Program Area is completing its first full CCSG cycle. The initial goal of the Program Area was to bring together the strong existing group of gene regulation researchers at UCLA and to develop a collective interest in the application of gene regulation studies to problems of cancer origin, development, and therapy. The original group of 12 has grown to 21 members, in large part by recruitment of a group of extraordinary young investigators as Assistant Professors. Substantial investment by the JCCC, the DGSoM, and the College of Letters and Science has benefited this Program Area enormously. During the current CCSG cycle, we have focused on four major objectives: (1) to promote among our members the study of fundamental mechanisms of gene regulation, using appropriate model organisms, mammalian cells, and animal models; (2) to study the molecular/transcriptional mechanisms that mediate cell differentiation, nflammation and viral latency and investigate how aberrations in these processes affect cancer initiation and progression; (3) to serve as a resource for the other Program Areas in the JCCC in the use of gene regulation concepts and methodologies to advance their research problems; and (4) to promote the translation of existing knowledge and new discoveries into translational and clinical applications. Interactions among members are fostered by a monthly meeting, a weekly journal club, and a seminar series that brings "leaders in the field" to UCLA.

基因调节计划区域由21名成员组成，涵盖了UCLA内的8个部门。在 ;过去的竞争周期，该计划的调查人员撰写了374个出版物，其中94个（25％）是 NTER-PROGRAGMATIC和15（4％）截面。 155（41％）放在高影响力期刊中。 15 该计划区域的成员使用了JCCC当前资助的8个共享资源中的8个。 在当前的资金年度，同行评审的资金总成本为1,220万美元，其中包括1.6美元 来自国家癌症研究所的百万。与其他计划领域一样，JCCC促进了许多交互式 活动和许多支持GR计划领域调查人员的共享资源。在 当前的赠款周期，以CCSG的发展基金，机构支持和 GR计划区的慈善礼物总计832,185美元。这些资金支持跨学科的赠款， 种子赠款，招聘/保留，计划领域的领导力支持，使用新兴共享的资金 资源和受训者。计划区域成员中有十二名是JCCC支持的接受者。 基因调节程序区域正在完成其第一个完整的CCSG周期。该计划的最初目标 区域是将强大的现有基因调节研究人员组合在一起，并开发 集体对将基因调节研究应用于癌症起源，发育和发育问题的兴趣 治疗。最初的12组已成长为21名成员，在很大程度上是招募一组 非凡的年轻调查员是助理教授。 JCCC，DGSOM的大量投资， 文学与科学学院已极大地使该计划领域受益。在电流期间 CCSG周期，我们关注的四个主要目标：（1）在我们的成员之间促进研究 基因调节的基本机制，使用适当的模型生物，哺乳动物细胞和 动物模型； （2）研究介导细胞分化的分子/转录机制 Nflammation和病毒潜伏期，并研究这些过程中的像差如何影响癌症的开始和 进展； （3）作为JCCC使用基因调节的其他计划领域的资源 概念和方法论可以推进他们的研究问题； （4）促进现有的翻译 知识和新发现转化为转化和临床应用。成员之间的互动是 由每月一次会议，每周期刊俱乐部和一个研讨会系列培养，将“领导者”带到 加州大学洛杉矶分校。