Bioinformatics Facility

生物信息学设施

基本信息

批准号：
7945001
负责人：
RAMANA V DAVULURI
金额：
$ 20.72万
依托单位：
WISTAR INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-15 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7945001
关键词：
Archives Area Arts Basic Cancer Research Binding Sites Bioinformatics Biological Assay Biology Biomedical Research Cancer Biology Cancer Center Cancer Research Project Clinical Collaborations Computational Biology Computer Simulation Computer software Consult Consultations Controlled Vocabulary Custom Data Data Analyses Data Base Management Data Security Data Set Databases Development Ensure Faculty Funding Future Gene Expression Genes Genome Genomics Housing Human Resources Image Individual Informatics Investments Laboratories Methods Microscopy Modeling Molecular Molecular Models Nucleic Acid Regulatory Sequences Patients Pharmacodynamics Process Proteomics Qualifying Reporting Research Research Personnel Resource Sharing Resources Reverse Transcriptase Polymerase Chain Reaction Semantics Services Slide Solutions Source Specialist Statistical Data Interpretation System Tissues Training Training Support Update Validation Vocabulary Work Writing anticancer research base cDNA Arrays computer science computerized data processing data integration data management data mining data portal design digital improved indexing instrumentation interoperability molecular modeling programs promoter protein function research facility research study response software development software systems square foot symposium tool transcription factor vector

项目摘要

The Bioinformatics Facility provides Cancer Center investigators with database management, software applications support, and expertise in statistical analyses and computational modeling of biomedical research data. In response to the growing informatics needs of funded Cancer Center researchers, the Bioinformatics Facility was established in 2001 with a combination of Cancer Center developmental funds and institutional support. The Cancer Center has made major investments to increase Bioinformatics facility space, instrumentation, and personnel over the past funding period. Under the direction of Dr. Ramana Davuluri, Director of Computational Biology, the Bioinformatics Facility has recently grown to consist of faculty, programmers, and statistical specialists from the Center for Systems and Computational Biology. Functions of the Facility reflect the research requirements of the three Cancer Center programs and are broadly divided into three areas: (i) data-management; (ii) statistical analyses and computational modeling; and (iii) advanced bioinformatics tools for integrative cancer biology. Specific services of the Bioinformatics Facility are to: 1) provide computational support for use of database software and bioinformatics tools; 2) provide consulting support regarding statistical design and data analyses for high-throughput experiments; 3) provide shared archives for high throughput molecular (both microarray and sequencing) data, tissue related data, image data, and pharmacodynamics data (extended and new service); and 4) adapt and implement cohesive analysis and data mining tools that allow for integration and cross-validation of the comprehensive molecular data used in integrative cancer biology research (new service in 2008). The Facility has placed a high priority on integrating cancer research information representing a variety of data types, including clinical patient data, molecular data from microarrays, massive-parallel sequencers (e.g. Illumina [Solexa] Genome Analyzer) and RT-PCR, and image data from digitized microscopy slides. Data security is a primary focus of the Bioinformatics Facility in designing and implementing software systems. The Facility also provides computational bioinformatics support to assist in the analysis of genomic, molecular, and proteomic data using commercial and locally-developed software packages. Most recently, the facility has been re-located into newly renovated space (2,006 sq. ft.), providing a state-ofthe- art server room and expanded office and conference room space.

生物信息学设施为癌症中心研究人员提供数据库管理，软件应用支持以及生物医学统计分析和计算建模方面的专业知识研究数据。为了应对资助的癌症中心研究人员日益增长的信息学需求，生物信息学设施成立于2001年，结合了癌症中心的发展基金和机构支持。癌症中心已经进行了重大投资以增加生物信息学设施在过去的资金期间，空间，仪器和人员。在拉马纳博士的指导下计算生物学总监Davuluri，生物信息学设施最近已成长为包括系统与计算生物学中心的教师，程序员和统计专家。该设施的功能反映了三个癌症中心计划的研究要求，并且广泛分为三个领域：（i）数据管理；（ii）统计分析和计算建模；（iii）综合癌症生物学的先进生物信息学工具。生物信息学的特定服务设施是：1）提供用于使用数据库软件和生物信息授权工具的计算支持； 2）提供有关统计设计和数据分析的咨询支持； 3）提供共享的档案，用于高吞吐量分子（微阵列和测序）数据，与组织相关的数据数据，图像数据和药效学数据（扩展和新服务）； 4）适应和实施具有凝聚力分析和数据挖掘工具，可允许整合和交叉验证综合综合癌症生物学研究中使用的分子数据（2008年的新服务）。该设施已放置在整合代表各种数据类型的癌症研究信息方面的优先级，包括临床患者数据，来自微阵列的分子数据，大量平行序列（例如Illumina [Solexa]基因组分析仪）和RT-PCR，以及来自数字化显微镜载玻片的图像数据。数据安全是设计和实施软件系统的生物信息学设施。该设施还提供计算生物信息学支持以帮助分析基因组，分子和蛋白质组学数据使用商业和本地开发的软件包。最近，该设施已重新置于新装修的空间（2,006平方英尺），提供了最先进的艺术服务器室，扩大办公室和会议室空间。