COBRE: RIH: THEME B: PATHOGENESIS OF GI TUMORS, GERD, ESOPHAGITIS, SUBTITLE:

COBRE：RIH：主题 B：胃肠道肿瘤、胃食管反流病、食管炎的发病机制，副标题：

• 批准号: 7960509
• 负责人: WEIBIAO CAO
• 金额: $ 14.67万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-10 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960509
• 关键词: Acids; Barrett Esophagus; Cells; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Esophageal Adenocarcinoma; Esophagitis; Exposure to; Funding; Gastroesophageal reflux disease; Gastrointestinal Neoplasms; Grant; Inflammatory; Institution; Metaplastic Cell; NCI Center for Cancer Research; Pathogenesis; Reactive Oxygen Species; Research; Research Personnel; Resources; Source; United States National Institutes of Health; cytokine; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will hypothesize that the release of reactive oxygen species (ROS) and proinflammatory cytokines from inflammatory cells and/or metaplastic cells of Barrett's esophagus (BE) following exposure to acid exposure promotes the development of esophageal adenocarcinoma(EA).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目将假设巴雷特食管 (BE) 暴露于酸后，炎症细胞和/或化生细胞释放活性氧 (ROS) 和促炎细胞因子，促进食管腺癌 (EA) 的发展。