FUNCTIONAL GENOMICS IN CLOSE WILD RELATIVES OF ARABIDOPSIS THALIANA

拟南芥近缘野生植物的功能基因组学

• 批准号: 7960310
• 负责人: DAVID SIEMENS
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960310
• 关键词: Affect; Arabidopsis; Biomedical Research; Computer Retrieval of Information on Scientific Projects Database; Environment; Evolution; Funding; Gene Expression Regulation; Genes; Genetic; Genetic Variation; Genomics; Glucosinolates; Grant; Growth; Institution; Measures; Mouse-ear Cress; Plants; Production; Relative (related person); Research; Research Infrastructure; Research Personnel; Resources; Source; South Dakota; Testing; United States National Institutes of Health; Variant; cost; functional genomics; theories; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Optimality theory for defense evolution (Hamilton et al. 2001 for overview), currently the best framework we have to understand the simultaneous evolution of defense and competitive ability in plants, predicts a tradeoff between defense and competitiveness because defense production is thought to divert limited resources away from competitive growth (Herms and Mattson 1992). We have tested for this evolutionary tradeoff by (1) studying the effects of genetic or environmental variation in defenses on competitive growth, and by (2) studying the effects of genetic variation in competitiveness on defense expression. Although we have detected costs of defenses manifest as reduced growth in the absence of herbivores, these costs were not detected in competitive environments (Siemens et al. 2002; Siemens et al. 2003). That is, defense production affected growth, but not competitive ability. We have also found evidence that measures of defense, such as glucosinolate concentration, were sometimes higher or competitively induced in better competitors. A competitive function for defensive genes would explain many of these results. The genomic tools of Arabidopsis allow us to determine whether competitors induce defensive genes, as one would expect for defenses that also function in competition. A genomic approach also allows a test for the predicted tradeoff between defense and competitive ability, which may further our understanding of gene regulation (Stearns and Magwene 2003).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 国防进化的最佳理论（Hamilton等，2001年概述），目前，我们必须了解国防和植物中国防能力的同时发展，可以预测国防和竞争力之间的权衡，因为认为国防生产被认为是将有限的资源转移到竞争性增长（Herms and Mattson 1992）中。 我们已经通过（1）研​​究遗传或环境变异对防御竞争增长的影响以及（2）研究遗传变异对竞争性对国防表达的影响的影响。 尽管我们发现防御成本在没有食草动物的情况下表现为降低的生长，但在竞争环境中未检测到这些成本（Siemens等，2002； Siemens等，2003）。 也就是说，国防产量影响了增长，但没有竞争能力。我们还发现证据表明，在更好的竞争者中，防御措施（例如葡萄糖苷酸盐浓度）有时会更高或有竞争力。防御基因的竞争功能将解释其中许多结果。拟南芥的基因组工具使我们能够确定竞争对手是否诱导防御基因，就像人们对也在竞争中起作用的防御能力一样。 一种基因组方法还可以测试防御能力和竞争能力之间的预测权衡，这可能会进一步了解我们对基因调节的理解（Stearns and Magwene 2003）。