HIPPOCAMPAL RADIAL MAPPING IN MCI PATIENTS: A LONGITUDINAL STUDY

MCI 患者海马径向测绘：一项纵向研究

• 批准号: 7955663
• 负责人: CRISTINA GEROLDI
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955663
• 关键词: Age; Aging-Related Process; Atrophic; Attention; Brain; Child; Clinical; Clinical Research; Cognitive; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Computer software; Consent; Dementia; Diagnosis; Diagnostic; Elderly; Enrollment; Epidemiologic Studies; Equilibrium; Ethics Committees; Female; Funding; Gait; Grant; Hippocampus (Brain); Hospitals; Image; Individual; Institution; Interview; Language; Life; Magnetic Resonance Imaging; Maps; Measures; Medial; Memory; Memory impairment; Methods; Modeling; Morphology; Natural History; Neurologic Examination; Participant; Patients; Performance; Persons; Phase Transition; Physical Function; Population; Protocols documentation; Radial; Research; Research Personnel; Resources; Slice; Source; Spouses; Structure; Surface; Syndrome; Testing; Thick; Thinking; Three-Dimensional Image; Time; United States National Institutes of Health; Visit; Weight; abstracting; base; clinical Diagnosis; computational anatomy; depression; depressive symptoms; executive function; follow-up; indexing; informant; mild neurocognitive impairment; morphometry; neuropsychological; normal aging; pre-clinical; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Mild cognitive impairment (MCI) is a clinical syndrome characterized by memory deficits without functional impact on daily living, and thus not severe enough to allow a diagnosis of dementia. Clinical studies of elderly individuals with MCI suggest a fast rate of progression to dementia. Memory impairment is usually the initial presentation of dementia in AD, suggesting that in the elderly population, significant memory impairment may be the transition phase between normal aging process and AD, therefore, MCI is considered as the pre-AD status. However, also for patients who develop some form of dementia different from AD, the transition from the normal cognitive state to clinically recognizable dementia occurs gradually over years. Participants and Methods: 104 patients (64% females, mean age 71+8 years) were evaluated from April 2002 to March 2005. Patients are taken from a prospective project on the natural history of MCI ("Mild Cognitive Impairment in Brescia - MCIBs"), aimed to study the natural history of non demented persons with apparently primary cognitive deficits. The study protocol was approved by the local ethics committee and all participants signed an informed participation consent. All of these underwent: (i) semi-structured interview with the patient and  whenever possible  with another informant (usually the patient's spouse or a child) by a geriatrician; (ii) physical and neurological examinations; (iii) performance-based tests of physical function, gait and balance; (iv) neuropsychological battery assessing verbal and non-verbal memory, attention and executive functions abstract thinking; language; and apraxia and visuo-constructional abilities; (v) assessment of depressive symptoms with the Center for Epidemiologic Studies Depression Scale (CES-D). They underwent brain magnetic resonance imaging in the neuroradiology department of the Citt¿ di Brescia Hospital, Brescia, with a 1.0 tesla Philips Gyroscan scanner with the following protocol: sagittal FFE 3D sequence (TR 10 ms, TE 4 ms, TI 700 ms, flip angle 10¿, FOV 250 mm, matrix 256¿256, slice thickness 1.3 mm), axial T2-DP sequence, and axial FLAIR. T1-weighted 3D images acquired in the sagittal plane were resliced into 2-mm thick slices in the coronal plane. Enrolled patients undergo an yearly follow-up visit consisting in complete clinical and neuropsychological examination. Conversion to dementia is diagnosed according with the clinical diagnostic criteria for AD, VaD, FTD, etc. On the MR images will be perform a hippocampal radial mapping analysis. In order to do this MRI images will be normalized by linear (12 parameter) transformation to a customized template using the Statistical Parametric Mapping (SPM99) software. The hippocampi will be manually traced according to a formal protocol with established inter- and intra-rater reliability and 3D parametric surface mesh models will be created to represent the hippocampus in each subject. To assess hippocampal morphology, a medial curve will be automatically defined as the 3D curve traced out by the centroid of the hippocampal boundary in each image slice. The radial size of each hippocampus at each boundary point will be assessed by automatically measuring the radial 3D distance from the surface points to the medial curve defined for individual's hippocampal surface model. Shorter radial distances will be used as an index of atrophy. Statistical maps will be generated indicating local group differences in radial hippocampal distance. Objectives and conclusion: The aim of our study is to perform a hippocampal radial mapping analysis for all patients and controls at baseline time and after one year. We will compare the hippocampal volume and morphometry between MCI converted and MCI not converted. The findings of this study could give important evidence for a better pre clinical diagnosis of dementia and in this way permit to set a better treatment.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 背景：轻度认知障碍（MCI）是一种临床综合征，其特征是记忆定义对日常生活没有功能影响，因此不足以允许诊断痴呆。 MCI基本个体的临床研究表明，痴呆症的进展很快。记忆障碍通常是AD中痴呆症的初步表现，这表明在基础人群中，重大记忆障碍可能是正常衰老过程和AD之间的过渡阶段，因此，MCI被视为AD的状态。但是，对于患有与AD不同形式的痴呆症的患者，从正常认知状态到临床识别痴呆症的过渡逐渐发生。 参与者和方法：从2002年4月到2005年3月，评估了104名患者（女性平均年龄为71岁，平均71岁+8岁）。患者是从MCI自然史（“ Brescia -MCIBS -MCIBS中的轻度认知障碍”中的前瞻性项目中，旨在研究非痴呆症的自然史，具有明显的原始认知性偏置性的自然史。该研究方案均由当地伦理委员会批准，所有参与者均签署了知情参与同意。所有这些都接受了：（i）与患者的半结构化访谈，并在可能的情况下与其他线人（通常是患者的配偶或子女）由老年医生进行； （ii）身体和神经系统检查； （iii）基于绩效的身体功能，步态和平衡测试； （iv）神经心理电池评估言语和非语言记忆，注意力和执行功能抽象思维；语言;以及缺陷和视觉构建能力； （v）评估抑郁症状的流行病学研究中心抑郁量表（CES-D）。 They underwent brain magnetic resonance imaging in the neuroradiology department of the Citt¿ di Brescia Hospital, Brescia, with a 1.0 tesla Philips Gyroscan scanner with the following protocol: sagittal FFE 3D sequence (TR 10 ms, TE 4 ms, TI 700 ms, flip angle 10¿, FOV 250 mm, matrix 256¿256, slice thickness 1.3 mm),轴向T2-DP序列和轴向天赋。将在矢状面中获取的T1加权3D图像重新固定为冠状平面的2毫米厚的切片。 入学的患者接受了每年的随访访问，包括完整的临床和神经心理学检查。根据AD，VAD，FTD等的临床诊断标准诊断为痴呆症。 在MR图像上将进行海马径向映射分析。为了完成此MRI图像，将使用统计参数映射（SPM99）软件进行线性（12个参数）转换为定制模板进行标准化。海马将根据具有建立的评估者间可靠性的形式协议手动追踪，并将创建3D参数表面网格模型以表示每个受试者的海马。为了评估海马形态，将自动将内侧曲线定义为每个图像切片中海马边界的质心所追踪的3D曲线。每个边界点的每个海马的径向大小将通过自动测量从表面点到定义为个人海马表面模型定义的内侧曲线的径向3D距离来评估。较短的径向距离将用作萎缩的指数。将生成统计图，表明径向海马距离的局部组差异。 目的和结论：我们研究的目的是在基线和一年后对所有患者和对照组进行海马径向映射分析。 我们将比较MCI转换的MCI和未转换的MCI之间的海马体积和形态测定法。 这项研究的结果可以提供重要的证据证明痴呆症的临床前诊断更好，并以这种方式可以设定更好的治疗方法。