FRACTAL DIMENSION IN HUMAN CEREBELLUM MEASURED BY MRI

通过 MRI 测量人类小脑的分形维数

• 批准号: 7955757
• 负责人: JINGZHI LIU
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955757
• 关键词: Adult; Autistic Disorder; Biology; Boxing; Brain imaging; Cerebellum; Computer Retrieval of Information on Scientific Projects Database; Development; Dimensions; Fractals; Funding; Grant; Human; Image; Institution; Magnetic Resonance Imaging; Measures; Medicine; Methods; Modeling; Patients; Research; Research Personnel; Resolution; Resources; Series; Skeleton; Source; Staging; Structure; United States National Institutes of Health; White Matter Disease; computational anatomy; indexing; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fractal dimension has been used to quantify the structures of a wide range of objects in biology and medicine. In this study we will measure the fractal dimension (FD) of human cerebellum (CB) using MR CB images. High resolution coronal MRI brain images covering the whole CB will be collected from healthy adult subjects and patients with white matter diseases (AUTISM, MS, etc.) CB images will be resampled to a series of image sets with different three-dimensional resolutions. At each resolution, the skeleton of the CB white matter will be obtained and the number of pixels belonging to the skeleton will be determined. Fractal dimension of the CB skeleton will be calculated using the box-counting method. Fractal dimension will be compared between the normal subjects group and patients group to quantify the structure changes. The fractal dimension may serve as a quantitative index for structural complexity and morphometric changes of the CB at its developmental, degenerative, diseased or evolutional stages.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 分形维数已被用来量化生物学和医学中各种物体的结构。在本研究中，我们将使用 MR CB 图像测量人类小脑 (CB) 的分形维数 (FD)。覆盖整个 CB 的高分辨率冠状 MRI 脑图像将从健康成人受试者和患有白质疾病（自闭症、多发性硬化症等）的患者中收集。CB 图像将被重新采样为一系列具有不同三维分辨率的图像集。在每个分辨率下，将获得CB白质的骨架，并确定属于该骨架的像素数量。 CB骨架的分形维数将使用盒计数法计算。将比较正常受试者组和患者组之间的分形维数以量化结构变化。分形维数可以作为CB在发育、退化、患病或进化阶段的结构复杂性和形态变化的定量指标。