FINE TIMING OF THE BOLD HEMODYNAMIC RESPONSE

大胆血流动力学反应的精确时机

• 批准号: 7954972
• 负责人: STEPHEN A. ENGEL
• 金额: $ 0.64万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954972
• 关键词: Applications Grants; Area; Computer Retrieval of Information on Scientific Projects Database; Data; Data Set; Development; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Joints; Link; Magnetic Resonance Imaging; Measurement; Modeling; Play; Process; Research; Research Personnel; Resources; Role; Source; Spectrum Analysis; Stimulus; Time; Time Study; United States National Institutes of Health; Work; blood oxygenation level dependent response; extrastriate visual cortex; hemodynamics; interest; millisecond; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data sets we have obtained from previous studies suggest a large (> 200 msec) difference in BOLD onset timing due to differences in stimulus strength: stronger responses may begin earlier than weaker ones. Although stimulus strength (such as contrast amplitude) is thought to result in small onset timing differences in the neural response in the LGN (Hartveit and Heggelund 1992), V1 (Reich et al 2001), and other visual areas (Gawne et al 1996), these small timing differences (10's of msec) are an order of magnitude smaller than what we have seen in the BOLD fMRI response. We propose to make fine measurements of the timing of the BOLD response using an fMRI sequence with a short TR, gathering one volume every 250 milliseconds. Should timing differences as a function of response strength exist, they would have a substantial impact in the field, as an increasing number of studies are investigating timing of neural response using fMRI. The timing differences may also impact work using dynamic causal modeling (DCM), in which timing is used to infer causal links between cortical areas (Stephan et al 2008, Mechelli et al 2003). The data obtained here will be key for several grant proposals which propose to use fMRI and joint fMRI/EEG to study timing of perceptual processes. Engel, Olman, Kersten, and He all have interests or proposals under development in which such measurements of timing may play an important role.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们从之前的研究中获得的数据集表明，由于刺激强度的差异，BOLD 开始时间存在很大（> 200 毫秒）差异：较强的反应可能比较弱的反应更早开始。尽管刺激强度（例如对比度幅度）被认为会导致 LGN（Hartveit 和 Heggelund 1992）、V1（Reich 等人 2001）和其他视觉区域（Gawne 等人 1996）的神经反应产生微小的起始时间差异。 ，这些小的时间差异（10 毫秒）比我们在 BOLD fMRI 响应中看到的小一个数量级。我们建议使用具有短 TR 的 fMRI 序列对 BOLD 响应的时间进行精细测量，每 250 毫秒收集一个体积。如果作为反应强度函数的时间差异存在，它们将会对该领域产生重大影响，因为越来越多的研究正在使用功能磁共振成像来研究神经反应的时间。时间差异还可能影响使用动态因果模型 (DCM) 的工作，其中时间用于推断皮质区域之间的因果关系 (Stephan et al 2008, Mechelli et al 2003)。这里获得的数据将是几项拨款提案的关键，这些提案提议使用功能磁共振成像和联合功能磁共振成像/脑电图来研究感知过程的时间安排。 Engel、Olman、Kersten 和 He 都有正在开发的兴趣或提案，其中这种时间测量可能发挥重要作用。