ANASTOMOSIS OF A LEFT VENTRICULAR ASSIST DEVICE

左心室辅助装置的吻合术

• 批准号: 7956195
• 负责人: KEEFE B MANNING
• 金额: $ 0.08万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956195
• 关键词: Anastomosis - action; Aorta; Biomedical Research; Cannulas; Computer Retrieval of Information on Scientific Projects Database; Computer software; Distal; Funding; Goals; Grant; Heart; Hemolysis; High Performance Computing; Institution; Left; Left ventricular structure; Modeling; Operative Surgical Procedures; Pattern; Plant Leaves; Plant Roots; Platelet Activation; Positioning Attribute; Pulsatile Flow; Research; Research Personnel; Resistance; Resources; Source; Thrombosis; United States National Institutes of Health; Work; aortic arch; aortic valve; base; ventricular assist device

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Left ventricular assist devices (LVADs)have been used extensively to assist or replace the function of a failing left heart. The LVAD is usually connected to the native heart between the apex of the left ventricle by the LVAD inflow cannula and to the aorta by the LVAD outflow cannula. Depending on the state of the heart, the LVAD can work in either serial or parallel conditions.Blood flow in the aorta can be highly disturbed by the anastomosis. A descending aortic outflow anastomosis is usually not employed due to its potential to generate stagnant flows associated thrombosis near the aortic valves (DiGiorgi et al., 2004). An ascending aortic anastomosis, however, can produce highly disturbed flows in the aorta, resulting in jet impingement on the aortic arch, unpredictable flow partitioning between the major secondary vessels, stagnant flow near the aortic root, and even turbulent flow under specific operating conditions. These high shear turbulent flows might cause platelet activation and hemolysis. Therefore, it is important to study flow patterns in the aorta based on different LVAD anastomotic configurations.The goal of the present study is to understand the influence of the outflow cannula anastomosis, in continuous and pulsatile flow conditions, using an object-oriented CFD software toolkit OpenFOAM (Open Field Operation and Manipulation) to compute the flow field. Both laminar and turbulent flows are studied under serial and parallel conditions. The aorta is assumed to be curved in one plane only. The flow partitioning between the secondary vessels is modeled by applying a resistance outflow boundary condition (Figueroa et al., 2006; Vignon-Clementel et al., 2006). Two different outflow cannula anastomotic configurations, including both proximal and distal positions, are considered.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 左心室辅助装置（LVAD）已被广泛用于辅助或替代衰竭左心的功能。 LVAD 通常通过 LVAD 流入插管连接至左心室心尖之间的原生心脏，并通过 LVAD 流出插管连接至主动脉。根据心脏的状态，LVAD 可以在串行或并行条件下工作。主动脉中的血流可能会受到吻合术的严重干扰。通常不采用降主动脉流出吻合术，因为它有可能在主动脉瓣附近产生与血栓形成相关的停滞血流（DiGiorgi 等，2004）。然而，升主动脉吻合术会在主动脉中产生高度扰动的血流，导致主动脉弓上的射流冲击、主要次要血管之间不可预测的血流分配、主动脉根部附近的停滞血流，甚至在特定操作条件下出现湍流。这些高剪切湍流可能导致血小板活化和溶血。因此，研究基于不同 LVAD 吻合配置的主动脉血流模式非常重要。本研究的目的是使用面向对象的 CFD 软件了解连续和脉动血流条件下流出套管吻合的影响用于计算流场的工具包 OpenFOAM（开放场操作和操纵）。在串行和并行条件下研究层流和湍流。假设主动脉仅在一个平面内弯曲。通过应用阻力流出边界条件对二级血管之间的流动分配进行建模（Figueroa 等人，2006 年；Vignon-Clementel 等人，2006 年）。考虑两种不同的流出套管吻合配置，包括近端和远端位置。