ANASTOMOSIS OF A LEFT VENTRICULAR ASSIST DEVICE

左心室辅助装置的吻合术

• 批准号: 7956195
• 负责人: KEEFE B MANNING
• 金额: $ 0.08万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956195
• 关键词: Anastomosis - action; Aorta; Biomedical Research; Cannulas; Computer Retrieval of Information on Scientific Projects Database; Computer software; Distal; Funding; Goals; Grant; Heart; Hemolysis; High Performance Computing; Institution; Left; Left ventricular structure; Modeling; Operative Surgical Procedures; Pattern; Plant Leaves; Plant Roots; Platelet Activation; Positioning Attribute; Pulsatile Flow; Research; Research Personnel; Resistance; Resources; Source; Thrombosis; United States National Institutes of Health; Work; aortic arch; aortic valve; base; ventricular assist device

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Left ventricular assist devices (LVADs)have been used extensively to assist or replace the function of a failing left heart. The LVAD is usually connected to the native heart between the apex of the left ventricle by the LVAD inflow cannula and to the aorta by the LVAD outflow cannula. Depending on the state of the heart, the LVAD can work in either serial or parallel conditions.Blood flow in the aorta can be highly disturbed by the anastomosis. A descending aortic outflow anastomosis is usually not employed due to its potential to generate stagnant flows associated thrombosis near the aortic valves (DiGiorgi et al., 2004). An ascending aortic anastomosis, however, can produce highly disturbed flows in the aorta, resulting in jet impingement on the aortic arch, unpredictable flow partitioning between the major secondary vessels, stagnant flow near the aortic root, and even turbulent flow under specific operating conditions. These high shear turbulent flows might cause platelet activation and hemolysis. Therefore, it is important to study flow patterns in the aorta based on different LVAD anastomotic configurations.The goal of the present study is to understand the influence of the outflow cannula anastomosis, in continuous and pulsatile flow conditions, using an object-oriented CFD software toolkit OpenFOAM (Open Field Operation and Manipulation) to compute the flow field. Both laminar and turbulent flows are studied under serial and parallel conditions. The aorta is assumed to be curved in one plane only. The flow partitioning between the secondary vessels is modeled by applying a resistance outflow boundary condition (Figueroa et al., 2006; Vignon-Clementel et al., 2006). Two different outflow cannula anastomotic configurations, including both proximal and distal positions, are considered.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 左心室辅助设备（LVADS）已被广泛使用，以帮助或替换左心脏失败的功能。 LVAD通常通过LVAD流入套管在左心室的顶点之间连接到本地心脏，并通过LVAD流出插管与主动脉相连。根据心脏的状态，LVAD可以在串行或平行状态下工作。主动脉中的血液流动可能会受到吻合术的高度干扰。由于其潜力在主动脉瓣附近产生与血栓形成相关的停滞流动，因此通常不采用降低主动脉流出吻合术（Digiorgi et al。，2004）。但是，主动脉吻合术会在主动脉中产生高度干扰的流动，从而导致主动脉弓上的射流撞击，主要二次血管之间的不可预测的流动分配，在主动脉根附近的停滞流量，甚至在特定操作条件下均匀湍流。这些高剪切湍流可能会导致血小板激活和溶血。因此，重要的是，基于不同的LVAD吻合构型研究主动脉中的流动模式。本研究的目的是使用面向对象的CFD CFD软件工具包（开放式操作和操作）来了解流出插管的连续和脉动流动条件下流出的插管吻合术的影响。在串行和平行条件下研究层流和湍流。假设主动脉仅在一个平面上弯曲。通过应用电阻流出边界条件来建模二次血管之间的流动分区（Figueroa等，2006； Vignon-Clementel等，2006）。考虑了两种不同的流出套管吻合构型，包括近端和远端位置。