ANALYSIS OF PROTEIN-PROTEIN INTERACTIONS AND QUASI-EQUIVALENCE IN VIRUS CAPSIDS

病毒衣壳中蛋白质-蛋白质相互作用和准等价性分析

• 批准号: 7957334
• 负责人: VIJAY S REDDY
• 金额: $ 2.74万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957334
• 关键词: Architecture; Capsid; Capsid Proteins; Computer Retrieval of Information on Scientific Projects Database; Environment; Funding; Grant; Institution; Knowledge; Measures; Property; Protein Subunits; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Viral; Virus; design; multi-scale modeling; novel; protein protein interaction; structural biology; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Viral capsids are composed of multiples copies of one or a few coat protein subunits. Knowledge on the extent of interactions of a capsid protein subunit in native and sometimes in non-native capsid environments will be of importance in understanding the relationship between the protein building block and the capsid size and architecture. Furthermore, the extent of similarity in the bonding and interactions of the subunits would point to the quasi-equivalences of subunits in viral capsids. The knowledge on the relationship between the type of the protein and the resulting capsid would aid in designing new and novel capsids. The objective of this project is to come up with measures/properties that would quantify the extent to which a subunit is involved in the protein-protein interactions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 病毒衣壳由一个或几个外壳蛋白亚基的多个拷贝组成。了解衣壳蛋白亚基在天然和有时在非天然衣壳环境中相互作用的程度对于理解蛋白质构建块与衣壳大小和结构之间的关系非常重要。此外，亚基键合和相互作用的相似程度表明病毒衣壳中亚基的准等效性。关于蛋白质类型和所得衣壳之间关系的知识将有助于设计新的衣壳。该项目的目标是提出量化亚基参与蛋白质-蛋白质相互作用的程度的测量/特性。