FUNCTION PROFILE OF UBIQUITIN RECEPTOR RPN13

泛素受体 RPN13 的功能概况

• 批准号: 7954676
• 负责人: Kylie J. Walters
• 金额: $ 0.49万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954676
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Degradation Pathway; Deubiquitinating Enzyme; Funding; Grant; Institution; Play; Research; Research Personnel; Resources; Role; Source; Techniques; Ubiquitin; United States National Institutes of Health; multicatalytic endopeptidase complex; protein degradation; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rpn13 is a proteasome component and newly identified as a ubiquitin receptor. Rpn13 is also the proteasomal receptor for a deubiquitinating enzyme Uch37. These make Rpn13 playing important roles in protein degradation pathway. The function profile of Rpn13 is expected to be elucidated by using modern NMR techniques.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Rpn13 是一种蛋白酶体成分，新近被鉴定为泛素受体。 Rpn13 也是去泛素化酶 Uch37 的蛋白酶体受体。这些使得Rpn13在蛋白质降解途径中发挥重要作用。 Rpn13 的功能概况有望通过现代 NMR 技术得到阐明。