ORAL MUCOSAL IMMUNITY IN VULNERABLE HIV INFECTED POPULATIONS

易受艾滋病毒感染人群的口腔粘膜免疫

• 批准号: 7956492
• 负责人: Catherine Marie Stein
• 金额: $ 0.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956492
• 关键词: AIDS/HIV problem; Aphthous Stomatitis; CCR5 gene; CXCR4 gene; Cells; Computer Retrieval of Information on Scientific Projects Database; Cytomegalovirus; Development; Frequencies; Funding; Genomics; Grant; HIV; HIV Infections; Hairy Leukoplakia; Human; Human Genetics; Immune system; Individual; Infection; Institution; Kaposi Sarcoma; Mediating; Mucosal Immunity; Natural Immunity; Oral; Oral candidiasis; Oral mucous membrane structure; Periodontitis; Play; Population; Predisposition; Proteomics; Research; Research Personnel; Resources; Role; Simplexvirus; Source; Susceptibility Gene; United States National Institutes of Health; Variant; antimicrobial; beta-Defensins; genetic analysis; oral wart; protein structure function; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The frequency of oral complications of HIV/AIDS; including oral candidiasis, Kaposi's sarcoma, aphthous ulcers, oral hairy leukoplakia, CMV, HSV, necrotizing ulcerative periodontitis, and oral warts have changed since the initial description of the infection in the 1980s. Human beta defensins play a central role in mucosal defenses by providing direct anti-microbial activity and by mediating cross-talk with cells of the adaptive immune system. This project aims to determine susceptibility to oral complications following HIV infection, by using proteomics, genomics, and protein structure/function approaches and to focus on innate immunity in the oral mucosa and human beta defensins. Genetic analyses will focus on the association between innate immunity genes and susceptibility to development of oral complications in HIV-infected individuals, and the association between copy number variants in beta defensin genes and susceptibility to CCR5 vs. CXCR4 co-receptor use in cellular entry of HIV.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 艾滋病毒/艾滋病的口服并发症的频率；包括口服念珠菌病，卡波西的肉瘤，腹部溃疡，口腔毛状白血病，CMV，HSV，坏死性溃疡性牙周炎和口腔疣自1980年代最初的感染以来发生了变化。 人β防御素通过提供直接的抗微生物活性并与适应性免疫系统的细胞进行介导，在粘膜防御中起着核心作用。该项目旨在通过使用蛋白质组学，基因组学和蛋白质结构/功能方法来确定艾滋病毒感染后口服并发症的敏感性，并专注于口服粘膜和人β防御素的先天免疫。 遗传分析将重点关注先天免疫基因与艾滋病毒感染者口服并发症发展的易感性之间的关联，以及β防御素基因中的拷贝数变异与CCR5易感性与CXCR4相对于CXCR4的易感性与CXCR4共同受体的易感性之间的关联艾滋病病毒。