SPECTROSCOPY OF HUMAN BRAIN AT 7T

7T 下的人脑光谱

• 批准号: 7956949
• 负责人: Changho Choi
• 金额: $ 1.78万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956949
• 关键词: Aminobutyric Acids; Brain; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Coupling; Detection; Discrimination; Disease; Funding; Glutamates; Glutamine; Glycine; Grant; Hippocampus (Brain); Human; Institution; Magnetic Resonance Spectroscopy; Measurement; Measures; Metabolism; Protons; Research; Research Personnel; Resources; Serine; Signal Transduction; Source; Spectrum Analysis; Techniques; United States National Institutes of Health; improved; in vivo; macromolecule; neuropsychiatry; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proton magnetic resonance spectroscopy (1H-MRS) provides an effective tool for measuring metabolites in the human brain noninvasively in vivo. High-field MRS benefits from the increased chemical shift dispersion and signal gain. Precise measurement of several clinically-important, low-abundance metabolites by standard 1H-MRS is often elusive even at 7T, due to the spectroscopic complexities arising from the scalar coupling effects and macromolecule baseline signals. The objectives of the research are to develop MRS techniques that provide improved inter-metabolite discrimination for detection of glycine, serine, N-acetylaspartyl-glutamate (NAAG), glutamine, g-aminobutyric acid, etc., at both 7T and 3T. The MRS studies focus on prefrontal and hippocampal regions which are experimentally challenging but have high relevance to several neuropsychiatric disorders.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 质子磁共振光谱（1H-MRS）为在体内无创的人脑中的代谢物提供了有效的工具。 高场MRS受益于化学移位分散和信号增益的增加。 由于标量耦合效应和大分子基线信号引起的光谱复杂性，因此即使在7T时，标准1H-MRS的几种临床重要，低实现代谢产物的精确测量也常常难以捉摸。 该研究的目的是开发MRS技术，这些技术可提供改进的甘氨酸，丝氨酸，N-乙酰基体甲基 - 谷氨酸（NAAG），谷氨酰胺，G-氨基丁酸等的检测。 MRS研究集中于实验上具有挑战性但与几种神经精神疾病具有很高相关性的前额叶和海马区域。