SYNTHESIS OF DOPA-MODIFIED PEG

多巴修饰 PEG 的合成

• 批准号: 7954601
• 负责人: B Craig Lee
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954601
• 关键词: Adhesions; Adhesives; Amino Acids; Area; Bacteria; Binding; Biocompatible; Biocompatible Coated Materials; Cells; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Dopa; Environment; Funding; Goals; Grant; Institution; Marines; Medical; Metals; Mussels; Polymers; Proteins; Research; Research Personnel; Resistance; Resources; Safety; Semiconductors; Source; Surface; Tissue Adhesives; United States National Institutes of Health; Water; aqueous; design; improved; interfacial; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Marine mussels are known to anchor themselves to underwater surfaces in turbulent intertidal zones. They secrete adhesive proteins that can rapidlycure to form adhesive plaques. It is believed that3,4-dihydroxyphenylalanine (DOPA), an amino acid found in MAPs at a contentas much as 25 mol%, is responsible for both strong interfacial binding and curing of these proteins. The goals of our research are to combine the water-resistant adhesive characteristics of DOPA and its derivatives with biocompatible, synthetic polymer for different biomedical applications. One aspect of our research is to design DOPA-modified polymers for the use as tissue adhesive or sealant, which exploits DOPA's ability to cure rapidly and to adhere to a wide variety of surfaces in an aqueous environment. Through the use of different synthetic polymers, it is possible to create novel bioadhesives with improved characteristics (i.e. water-resistant adhesion, biodegradability, and safety) as compared to existing medical adhesives. Another research area focuses on combining DOPA with antifouling polymers to create coating materials that can repel proteins, cells, and bacteria. These coatings can render different surfaces resistant to cell and bacteria adhesion ranging from metals, semiconductors, and synthetic polymers.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 众所周知，海洋贻贝将自己固定在湍流的潮间带中的水下表面。他们分泌可以快速辨认形成粘合剂斑块的粘附蛋白。 据认为，在含量高达25 mol％的地图中发现的氨基酸为3,4-二羟基苯基丙氨酸（DOPA），是这些蛋白质的强界面结合和固化的原因。 我们研究的目标是将DOPA及其衍生物的防水粘合剂特性与生物相容性的合成聚合物相结合，用于不同的生物医学应用。 我们研究的一个方面是设计DOPA改性的聚合物，以用作组织粘合剂或密封剂，该聚合物利用了DOPA在水性环境中迅速固化并粘附到各种表面的能力。通过使用不同的合成聚合物，与现有的医学粘合剂相比，可以创建具有改善特性（即耐水粘附，生物降解性和安全性）的新型生物粘附剂。 另一个研究领域的重点是将DOPA与抗糊状聚合物结合起来，以创建可以驱除蛋白质，细胞和细菌的涂层材料。 这些涂层可以使不同的表面具有对细胞，细菌粘附的抗性，范围从金属，半导体和合成聚合物。