ANIMAL CORE

动物核心

基本信息

批准号：
7500741
负责人：
ALAN W HELDMAN
金额：
$ 13.48万
依托单位：
CEDARS-SINAI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7500741
关键词：
Accreditation Acetates Adult Aliquot American Amoxicillin Anatomy Anesthesia procedures Angiography Animal Care and Use Committees Animal Experimentation Animal Experiments Animal Hospitals Animal Housing Animal Model Animals Anterior Anterior Descending Coronary Artery Antibiotic Prophylaxis Antibiotics Apical Applications Grants Area Arts Aspirin Balloon Occlusion Bandage Benzathine Penicillin Biochemical Biopsy Blood Blood flow Blood gas Bolus Infusion Bone Marrow Boston Buprenorphine Caliber Cardiac Cardiac Catheterization Procedures Cardiac Surgery procedures Cardiology Cardiopulmonary Bypass Cardioscopes Cardiovascular Diseases Cardiovascular Models Cardiovascular system Carotid Arteries Catheterization Catheters Cefazolin Cells Charge Chemistry Chest Chest Tubes Clinic Clinical Research Clinical Trials Clip Condition Congestive Heart Failure Coronary Coronary Vessels Coronary artery Coronary sinus structure Daily Data Defibrillators Development Devices Diagnostic Diltiazem Distal Ear Economic Inflation Electric Countershock Electrocardiogram Electrocoagulation Employee Strikes Endocardium Ensure Epicardium Equipment Family suidae Fentanyl Film Fluoroscopy Gene Delivery Gentamicins Heart Heparin Hospitals Hour Housing Human Image Indwelling Catheter Infarction Infection Inferior Inferior vena cava structure Infusion procedures Injection of therapeutic agent Institution Institutional Policy Intervention Intramuscular Intravenous Bolus Investigation Ireland Irrigation Ischemia Ketamine Laboratories Laboratory Animals Laboratory Research Left Left ventricular structure Letters Lidocaine Lighting Measurement Mechanical Ventilators Mechanical ventilation Mediastinal Mesenchymal Stem Cells Metric Modeling Molecular Monitor Muscle Cells Myocardial Myocardial Infarction Myocardial dysfunction Myocardial tissue Myocardium Neck Needles Operating Rooms Operative Surgical Procedures Oxygen Pain Pain management Participant Pentobarbital Sodium Percutaneous Transluminal Coronary Angioplasty Performance Pericardial body location Pharmaceutical Preparations Phosphate Buffer Physiological reperfusion Physiology Placement Plastics Postoperative Period Preparation Procedures Production Protocols documentation Ptosis Radiology Specialty Records Recovery Recovery Room Regulation Reperfusion Therapy Research Resources Resuscitation Right atrial structure Safety Saline Sampling San Francisco Secure Services Shapes Site Skin Solutions Stem cells Sterility Sterilization for infection control Sternotomy Sternum Surgical Clips Surgical sutures Sus scrofa System Techniques Technology Thoracic aorta Time Tissues Training Translational Research Translations Triton Ultrasonics Ultrasonography Universities Veins Venous Ventricular Ventricular septum Visual Work animal care animal resource aortic valve auricular appendage base chiron vaccine clinical application day digital experience hemodynamics human subject in vivo instrument instrumentation novel pericardial sac pressure programs research study size success tool xanthine oxidase inhibitor

项目摘要

The Animal Core will provide expertise in planning, performing, and interpreting experiments performed in large animal models of human cardiovascular disease. The resources of the Animal Core allow humane and efficient utilization of swine for survival surgery, catheterization procedures, and hemodynamic assessments. These resources have operated smoothly through a variety of other translational research programs including the development of cardiovascular devices and diagnostic tools; large animal experiments in our area have led in many cases directly to human clinical trials. For the projects in this proposal, preparation and instrumentation of swine to model ischemic myocardial dysfunction will be done by techniques established and operating in our group. Delivery of bone marrow derived mesenchymal stem cells and of cardiac stem cells to swine hearts in vivo will be done under conditions and using devices which mimic and parallel planned clinical studies. The director of the Animal Core is also a key participant in the clinical trials in Projects 1 and 3, and the use of newer cell delivery techniques in the swine model will benefit the safety of human subjects in the clinical studies, as the experience gained in the Animal Core transfers directly to the clinical studies.

动物核心将提供在人类心血管疾病大型动物模型中进行的实验的规划、执行和解释方面的专业知识。动物核心的资源允许人道且高效地利用猪进行生存手术、导管插入手术和血流动力学评估。这些资源通过各种其他转化研究项目顺利运作，包括心血管设备和诊断工具的开发；我们领域的大型动物实验在许多情况下直接导致了人体临床试验。对于本提案中的项目，将通过我们小组建立和运行的技术来制备和仪器化猪以模拟缺血性心肌功能障碍。将骨髓间充质干细胞和心脏干细胞体内输送到猪心脏将在模拟和平行计划的临床研究的条件和设备下进行。动物核心主任也是项目1和项目3临床试验的主要参与者，在猪模型中使用更新的细胞递送技术将有利于临床研究中人类受试者的安全，因为在临床研究中获得的经验动物核心直接转移到临床研究。