EFFECTS OF CHOCOLATE ON CARDIOVASCULAR RISK FACTORS

巧克力对心血管危险因素的影响

• 批准号: 7951328
• 负责人: SHELIA G WEST
• 金额: $ 4.71万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951328
• 关键词: Acute; Adult; Age; Angiotensins; Antihypertensive Agents; Antioxidants; Beverages; Blood; Blood Pressure; Blood Vessels; Body mass index; Cardiovascular system; Chocolate; Clinical Research; Cocoa Powder; Computer Retrieval of Information on Scientific Projects Database; Consumption; Crossover Design; Diabetes Mellitus; Enrollment; Exposure to; Flavonols; Funding; Glucose; Glycosylated hemoglobin A; Goals; Grant; Hormonal; Hormones; Hour; Hypotension; Individual; Inflammatory; Institution; Insulin; Life; Lipids; Measures; Moods; Obesity; Overweight; Physiologic pulse; Population; Psychological Stress; Randomized; Renin; Reporting; Research; Research Personnel; Resources; Rest; Risk Factors; Saliva; Screening procedure; Source; Stress; Systemic disease; Testing; United States National Institutes of Health; Urine; Visit; cardiovascular risk factor; cytokine; design; mortality; normotensive; polyphenol; primary outcome; response; stressor; sugar; treatment duration; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cocoa is a rich source of antioxidant polyphenols and frequent consumption of cocoa and dark chocolate is associated with significant reductions in mortality and improvements in a number of CVD risk factors including blood pressure and vascular endothelial function. The primary goal of this study is to examine the effects of cocoa-derived polyphenols on several markers of cardiovascular risk, including cardiovascular and hormonal responses to psychological stress. This project builds on recent studies showing significant reductions in blood pressure after consumption of dark chocolate and cocoa. Grassi et al reported that 24-hour ambulatory blood pressure was significantly reduced by flavonol-rich dark chocolate in both normotensive and hypertensive individuals. This suggests that the hypotensive effects of cocoa are not restricted to controlled resting conditions, and that lower blood pressure may also be evident during exposure to stress in daily life. We propose to enroll 35 healthy adults, ages 40-65, who are typical of the US population (having body mass index in the overweight to obese range but without diabetes or other systemic disease). Our goal is to complete testing on 30 subjects who will be exposed to high polyphenol dark cocoa or a matched low polyphenol chocolate for 4 weeks each in a crossover design. The design includes a screening visit and a 2 -4 week washout between treatments. High polyphenol cocoa (22 g/d) will be delivered in a sugar-free cocoa beverage and a 37 g bar of dark chocolate. Primary outcomes to be measured before randomization and at the end of each treatment period include: cardiovascular and hormonal reactivity to acute stressors, mood, vascular endothelial function, pulse wave amplitude, and several other CVD risk factors measured in blood, saliva and urine. These include renin/ACE/angiotensin, lipids, inflammatory cytokines, insulin, glucose, HbA1c, and urinary stress hormones.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 可可是抗氧化剂多酚的丰富来源，可可和黑巧克力的频繁消费与死亡率的显着降低以及许多CVD风险因素的改善有关，包括血压和血管内皮功能。 这项研究的主要目的是检查可可衍生的多酚对心血管压力的多种心血管和荷尔蒙反应，包括对心理压力的多种标志。 该项目基于最近的研究，该研究表明，消耗黑巧克力和可可后血压的大幅降低。 Grassi等人报道说，在正常性和高血压个体中，富含黄酮醇的黑巧克力可显着降低24小时的门诊血压。这表明可可的降压作用不仅限于受控的静息条件，而且在日常生活中承受压力期间，血压也可能很明显。 我们建议招募35名40-65岁的健康成年人，他们是美国人口的典型成年人（在超重到肥胖范围内具有体重指数，但没有糖尿病或其他全身性疾病）。 我们的目标是完成30名受试者的测试，这些受试者将在跨界设计中暴露于高多酚深色可可或匹配的低多酚巧克力中4周。 该设计包括筛查访问和两次治疗之间的2 -4周冲洗。 高多酚可可（22 g/d）将以无糖的可可饮料和37 g的黑巧克力进行交付。在随机分组之前和每个治疗期结束时要测量的主要结果包括：对急性应激源的心血管和激素反应性，情绪，血管内皮功能，脉搏波振幅以及其他几种在血液，唾液和尿液中测得的CVD风险因素。其中包括肾素/ACE/血管紧张素，脂质，炎性细胞因子，胰岛素，葡萄糖，HBA1C和尿应激激素。