PROTEOMICS OF CEREBROSPINAL FLUID IN CFS

CFS 脑脊液蛋白质组学

• 批准号: 7951995
• 负责人: JAMES N BARANIUK
• 金额: $ 17.87万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951995
• 关键词: Area; Blood Pressure; Breathing; Burn injury; Capsaicin; Cerebrospinal Fluid; Chili Pepper; Chronic Fatigue Syndrome; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diagnostic tests; Dose; Esthesia; Exercise stress test; Fibromyalgia; Forearm; Funding; Grant; Hand; Headache; Heart Rate; Hypersensitivity; Hypersensitivity skin testing; Institution; Lung Capacity; Migraine; Neuraxis; Neurologic Dysfunctions; Noise; Pain Threshold; Participant; Pattern; Pharmaceutical Preparations; Photophobia; Population; Proteins; Proteomics; Pulmonary function tests; Redness; Research; Research Personnel; Resources; Shortness of Breath; Skin; Source; Spinal Puncture; Spinal Tap; Testing; United States National Institutes of Health; Work; grasp; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neurological dysfunction is a key component of the clinical expression and case designation of chronic fatigue syndrome (CFS), fibromyalgia (FM)and other related conditions.If the central nervous system is involved, then evidence will be present in the cerebrospinal fluid. Distinct patterns of proteins will be present in Chronic fatigue syndrome (CFS) compared to healthy control (HC) subjects. Other testing in our study would include,1. Assessment of lung capacity and scoring the shortness of breath as a result of breathing testing also called as the Pulmonary function testing (PFT). 2. Compare the blood pressure and heart rate response before and after hand grip exercise testing. 3. Skin tests like the i) Capsaicin skin test, to check for specific responses like burning sensation, area of skin redness, itchy sensation to varying doses of capsaicin (essence of chilli pepper), when placed on the forearm and to compare if there are any differences seen between the responses in CFS and Healthy controls. ii) Allergy skin test to look if there are any allergies that are seen in the set of CFS population. 4. 18 tenderness point testing to compare the pain threshold before and after the lumbar puncture also know as the spinal tap. 18 tenderness point testing is a diagnostic test for Fibromyalgia. 5. Many of the participants with CFS do have associated Migraine headaches and they complain of severe light sensitivity and loud noises could give them headache. We are analysing those group of people and decision have to be made as to which medications would work at best and give them immediate relief from headache in these group of participants.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 神经功能障碍是临床表达和慢性疲劳综合征（CFS），纤维肌痛（FM）和其他相关状况的病例指定的关键组成部分。与健康对照组（HC）受试者相比，慢性疲劳综合征（CFS）中将存在不同的蛋白质模式。 我们研究中的其他测试包括1。呼吸测试的评估和评估肺部能力短，也称为肺功能测试（PFT）。 2。比较手抓紧运动前后的血压和心率反应。 3。诸如I）辣椒素皮肤测试之类的皮肤测试，以检查特定的反应，例如燃烧的感觉，皮肤发红面积，发痒的感觉对各种剂量的辣椒素（辣椒的本质）（将其放在前臂上），并比较是否在CFS中有任何差异和健康对照组之间有任何差异。 ii）过敏皮肤测试，以查看CFS种群中是否有任何过敏。 4。18压痛点测试比较腰穿之前和之后的疼痛阈值，也称为脊柱水龙头。 18压痛点测试是纤维肌痛的诊断测试。 5。许多CFS的参与者确实具有偏头痛的头痛，他们抱怨严重的光敏性和响亮的声音可能会使他们头痛。我们正在分析这些人群，必须决定哪些药物可以起作用，并使他们立即缓解这些参与者的头痛。