CLINICAL TRIAL: MIRAGE

临床试验：幻影

• 批准号: 7951424
• 负责人: Thomas O Obisesan
• 金额: $ 0.1万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951424
• 关键词: Acceleration; African American; Age; Alzheimer' s Disease; Attention; Blood Pressure; Blood Vessels; Brain; Brain imaging; Canada; Caucasians; Caucasoid Race; Child; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; DNA; Data; Disease; Epidemiologic Studies; Epidemiology; Ethnic group; Funding; Genetic; Germany; Grant; Health; Injury; Institution; Japanese American; Life; Magnetic Resonance Imaging; Mirage; Nerve Degeneration; Patients; Plasma; Population; Predisposition; Process; Protein Isoforms; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; Siblings; Source; Spouses; United States National Institutes of Health; Universities; cerebrovascular; meetings; neuroimaging; proband

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In MIRAGE III, the researchers are turning their attention to the growing body of evidence from pathological, epidemiological and genetic studies that risk factors for vascualar disease also enhance the risk of AD. However, since most epidemiological studies lack neuroimaging data, it is unclear whether the apparent association between vascular risk factors and AD is medicated via ischemic injury to the brain, acceleration of the primary Alzheimer's neurodegenerative process, or some other process. Some vascular risk factors are more prevalent in African American and Japanese American populations than in Caucasians. The researchers involved in vascular function and other indicators of cerebrovascular health including blood pressure and structural brain imaging (MRI), and susceptibility to AD in these ethnic groups. In order to carry out this project successfully, a sample of 1000 patients (500 Caucasians, 300 African Americans, 200 Japanese Americans) who meet NINCDS/ADRDA critera for probable or definite AD from 11 centers in the US, Canada and Germany will be collected from the probands and living siblings, spouses and children over the age of 50 years. DNA, plasma A beta isoforms and MRI of the brain will be evaluated in probands and siblings.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在 MIRAGE III 中，研究人员将注意力转向来自病理学、流行病学和遗传学研究的越来越多的证据，这些证据表明血管疾病的危险因素也会增加 AD 的风险。 然而，由于大多数流行病学研究缺乏神经影像学数据，目前尚不清楚血管危险因素与 AD 之间的明显关联是否是通过大脑缺血性损伤、原发性阿尔茨海默氏症神经退行性过程加速或其他过程来调节的。 一些血管危险因素在非裔美国人和日裔美国人中比白种人更普遍。 研究人员研究了这些种族群体的血管功能和其他脑血管健康指标，包括血压和结构性脑成像 (MRI)，以及 AD 的易感性。 为了成功开展该项目，将从美国、加拿大和德国的 11 个中心收集符合 NINCDS/ADRDA 标准的可能或确诊 AD 的 1000 名患者样本（500 名白种人、300 名非裔美国人、200 名日裔美国人）来自先证者和活着的兄弟姐妹、配偶和50岁以上的孩子。 将在先证者和兄弟姐妹中评估 DNA、血浆 Aβ 同种型和大脑 MRI。