GASTROPARESIS REGISTRY

胃轻瘫登记处

• 批准号: 7951394
• 负责人: KENNETH L KOCH
• 金额: $ 7.15万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951394
• 关键词: Affect; Chronic; Classification; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnostic; Disease; Functional disorder; Funding; Gastroparesis; Grant; Institution; Knowledge; Methods; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Nausea; Pain; Patients; Physiological; Recruitment Activity; Registries; Research; Research Personnel; Resources; Satiation; Severities; Societies; Source; Symptoms; Testing; Tissues; United States National Institutes of Health; Vomiting; Woman; Affect; Chronic; Classification; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnostic; Disease; Functional disorder; Funding; Gastroparesis; Grant; Institution; Knowledge; Methods; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Nausea; Pain; Patients; Physiological; Recruitment Activity; Registries; Research; Research Personnel; Resources; Satiation; Severities; Societies; Source; Symptoms; Testing; Tissues; United States National Institutes of Health; Vomiting; Woman

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastroparesis is a devastating disease affecting predominantly young women. The symptomatic profile of gastroparesis includes nausea (90% of patients), vomiting (>80%), pain (~50%), early satiety (60%) and bloating (75%) and can vary in both the combination of symptoms and their severity. Because of its chronic, and often intractable nature, the disorder has a tremendous impact on both patients and society at large. Gastroparesis remains difficult to treat, in large part because of the lack of knowledge of the underlying pathophysiology of this disease. Several factors, in particular, have impeded the progress in this field including the paucity of patients seen by any one center, the absence of uniform diagnostic criteria, the lack of generally available, reliable methods for physiological testing and the inaccessibility of tissue for histopathological correlation. Given the complexity of the problem, and the profound degree of morbidity currently associated with this disorder, a compelling need exists to study patients in a systematic, concerted manner. Such studies can best be achieved by recruiting patients and collecting data from multiple centers as part of a large network of investigators focused on this disorder. In recognition of this fact, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the mechanism of RFA DK 05 004, established the Gastroparesis Clinical Research Consortium in 2006.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 胃轻瘫是一种毁灭性的疾病，主要影响年轻女性。 胃轻瘫的症状特征包括恶心（90％的患者），呕吐（> 80％），疼痛（〜50％），早期饱腹感（60％）和腹胀（75％），并且症状和严重程度的组合可能会有所不同。由于其慢性且通常是棘手的性质，该疾病对患者和整个社会都有巨大影响。胃轻瘫仍然很难治疗，这在很大程度上是由于缺乏对该疾病的基本病理生理学的了解。尤其是几个因素阻碍了该领域的进展，包括任何一个中心看到的患者缺乏患者，缺乏统一的诊断标准，缺乏可用于生理测试的一般可靠方法以及组织病理学相关性的组织不可接受。鉴于问题的复杂性以及目前与这种疾病相关的高度发病率，因此存在着以系统的，协调的方式研究患者的迫切需求。最好通过招募患者并从多个中心收集数据，这是一个专注于这种疾病的大型研究人员网络的一部分。为了认识到这一事实，国家糖尿病和消化和肾脏疾病研究所（NIDDK）通过RFA DK 05 004的机制于2006年建立了胃肉食临床研究联盟。