VITAMIN D INSUFFICIENCY AS AN INTERVAL CAUSE OF DIMINISHED BONE MINERAL DENSITY

维生素 D 不足是骨矿物质密度降低的间歇性原因

• 批准号: 7952183
• 负责人: Martin HEWISON
• 金额: $ 0.09万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952183
• 关键词: Aftercare; Blood specimen; Bone Density; Clinic; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Development; Frequencies; Funding; Genes; Grant; Immune system; Infection; Institution; Intervention; Leukocytes; Medicine; Osteoporosis; Patient Care; Patients; Pharmaceutical Preparations; Play; Prevalence; Procedures; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Vitamin D; Vitamin D Deficiency; bisphosphonate; bone; bone health; design; fighting; improved; meetings; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to assess the prevalence of interval Vitamin D deficiency in patients not responding to therapy with bisphosphonates for the treatment of osteoporosis. Patients meeting pre-defined criteria of "non-response" will be screened for vitamin D deficiency, and in those cases where deficiency is found, will have vitamin D replaced in order to see if this restores response to bisphosphonates. ¿Bisphosphonates¿ are a class of medications used to treat weak bones or ¿osteoporosis¿. A special type of x-ray known as a ¿DEXA Scan¿ is usually done annually to see whether patients are responding to these medicines. Normally, there is an increase in the density of the bones (BMD) while on these medicines. A decline in bone density while on bisphosphonate treatment suggests a separate so-called ¿secondary¿ cause of osteoporosis may have developed. One such secondary cause is the development of vitamin D insufficiency. The purpose of this study is to answer the following two questions: 1. What is the frequency of vitamin D deficiency in patients who have had a decline in BMD? 2. In patients with vitamin D deficiency and a decline in BMD, does replacement of vitamin D cause a rebound increase in BMD ? It is expected that the study will determine the prevalence of vitamin D insufficiency in a group of patients whose bone health is dependent on the administration of bisphosphonates. It is also anticipated that in those patients who have low vitamin D, replacing it will improve their BMD. We believe that the proposed research questions can be answered in the setting of standard patient care. That is to say, this research will not require any interventions or procedures beyond what is normally required in a bone clinic. In addition to its role in bone health, vitamin D plays a key role in our immune system, helping fight infection. Accordingly, as a separate study, we wish to study the white blood cells of stored samples of blood to analyze gene changes before and after treatment with vitamin D. We can do this with samples of blood collected for clinical reasons.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 这项研究旨在评估未对双膦酸盐治疗治疗骨质疏松症治疗的患者间隔维生素D缺乏症的患病率。符合“无反应”预定标准的患者将筛查维生素D缺乏症，在发现缺乏症的情况下，将更换维生素D，以查看这是否恢复对双膦酸盐的反应。 双膦酸盐是一种用于治疗弱骨头或骨质疏松症的药物。通常每年进行一种被称为Dexa扫描的X射线射线，以查看患者是否对这些药物做出反应。通常，在这些药物上，骨骼密度（BMD）的密度有所增加。双膦酸盐治疗时骨密度下降表明，可能已经出现了单独的所谓骨质疏松症原因。这样的次要原因是维生素D不足的发展。这项研究的目的是回答以下两个问题： 1。在BMD下降的患者中，维生素D缺乏症的频率是多少？ 2。在维生素D缺乏症和BMD下降的患者中，维生素D的替代是否会导致BMD的反弹增加？ 预计该研究将确定一组骨骼健康取决于双膦酸盐的患者中维生素D不足的患病率。还可以预料，在那些维生素D低的患者中，取代其将改善其BMD。我们认为，在标准患者护理的情况下，可以回答拟议的研究问题。也就是说，这项研究将不需要除骨诊所通常需要的任何干预措施或程序。 除了其在骨骼健康中的作用外，维生素D在我们的免疫系统中起着关键作用，有助于抵抗感染。根据另一项研究，我们希望研究储存的血液样本的白细胞，以分析使用维生素D治疗前后基因的变化。我们可以出于临床原因与收集的血液样本一起进行。