Schizophrenia risk to onset: Neurobiology and prevention

精神分裂症的发病风险：神经生物学和预防

基本信息

批准号：
7212068
负责人：
CHERYL MARY CORCORAN
金额：
$ 17.67万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7212068
关键词：
Acquired Immunodeficiency Syndrome Address Adolescent Adolescent Development Affect Agreement Alcohol or Other Drugs use Anti-Anxiety Agents Antidepressive Agents Antipsychotic Agents Antiviral Agents Anxiety Anxiety Disorders Area Attention Award Cannabis Categories Certificate of Confidentiality Circadian Rhythms Clinic Clinical Clinical Research Cognition Cognitive Cohort Studies Complex Cox Models Data Data Analyses Disease susceptibility Drug usage Early-life trauma Equipment and supply inventories Event Exclusion Criteria Failure Family Family history of Funding Genetic Goals HIV HPSE gene Habits Health Heterogeneity Hospitals Hydrocortisone Incipient Schizophrenia Individual Informed Consent Knowledge Laboratories Lead Life Logistic Regressions Longitudinal Studies Measures Mediating Mediator of activation protein Medical Medical History Mentored Patient-Oriented Research Career Development Award Methodology Mitochondrial Carnitine Palmitoyltransferase Pathway Modeling Moods Neurobiology Neuropsychology Normal Range Numbers Outcome Parents Patients Pattern Pharmaceutical Preparations Prevention Principal Investigator Property Prospective Studies Protocols documentation Proxy Psychometrics Psychosocial Stress Psychotic Disorders Relative (related person)Research Research Personnel Research Subjects Research Training Resources Risk Risk Factors Role Salivary Sampling Schizophrenia Signal Transduction Social Development Source Statistical Models Stress Supervision Survival Analysis Symptoms Testing Time Toxicology Training Urine career depressive symptoms experience help-seeking behavior hypothalamic-pituitary-adrenal axis interest men neuropsychological performance tests prevention evaluation prospective psychosocial relating to nervous system skills stressor young adult

项目摘要

DESCRIPTION (provided by applicant): This revised application for a Mentored Patient-Oriented Research Career Development Award (K23) presents a plan for Dr. Cheryl Corcoran to pursue training and research in the prospective assessment of the schizophrenia prodrome, specifically risk factors, intervening variables and markers associated with the onset of psychosis. The goals of the training and research plan are integrated around the hypothesis that the neural diathesis of schizophrenia liability involves a vulnerability to develop psychosis in the context of psychosocial stress. Dr. Corcoran currently has experience in studying 1) the schizophrenia prodrome and 2) stress exposure and its correlates in schizophrenia. Under the sponsorship of Dr. Malaspina, and drawing upon resources at both NYSPI/Columbia and Hillside Hospital, Dr. Corcoran's training plan combines formal coursework and direct supervision with clinical research experience and training. Dr. Corcoran has established a prodromal research clinic at NYSPI, entitled the "Center of Prevention and Evaluation" (COPE). The training plan involves 1) clinical methodologies in the assessment of stress and the HPA axis in schizophrenia (Malaspina); 2) increased expertise in prodromal research and neuropsychology (Cornblatt); 3) data analysis in longitudinal studies (Begg) and 4) adolescent cognitive and social development (Kestenbuam). The research plan is a prospective cohort study of prodromal patients that employs clinical methodologies that probe HPA axis function, prodromal symptoms, and psychosocial stress exposure. The hypotheses are that baseline stress-reactivity (stress reactive cortisol and impaired tolerance to normal stress) and intervening life events will increase risk for psychosis in prodromal patients. Important covariates are also evaluated, including cognition, early trauma, and medication and substance use. This study will provide the applicant with the knowledge and research experience necessary to apply for an R01 to further evaluate risk factors, mediators and markers of psychosis onset in prodromal patients.

描述（由申请人提供）：本修订后的以患者为导向的研究职业发展奖 (K23) 申请为 Cheryl Corcoran 博士提出了一项计划，旨在对精神分裂症前驱症状进行前瞻性评估，特别是风险因素、干预措施方面的培训和研究。与精神病发作相关的变量和标记。培训和研究计划的目标围绕这样一个假设：精神分裂症的神经素质涉及在心理社会压力的背景下发展精神病的脆弱性。 Corcoran 博士目前在研究 1) 精神分裂症前驱症状和 2) 压力暴露及其与精神分裂症的相关性方面拥有丰富的经验。在 Malaspina 博士的赞助下，并利用 NYSPI/哥伦比亚和 Hillside 医院的资源，Corcoran 博士的培训计划将正式课程和直接监督与临床研究经验和培训结合起来。 Corcoran 博士在 NYSPI 建立了一个前驱研究诊所，名为“预防和评估中心”(COPE)。培训计划涉及 1) 精神分裂症 (Malaspina) 压力和 HPA 轴评估的临床方法； 2）增加前驱研究和神经心理学方面的专业知识（Cornblatt）； 3）纵向研究中的数据分析（Begg）和4）青少年认知和社会发展（Kestenbuam）。该研究计划是一项针对前驱患者的前瞻性队列研究，采用临床方法来探讨 HPA 轴功能、前驱症状和社会心理压力暴露。假设基线压力反应性（压力反应性皮质醇和对正常压力的耐受性受损）和干预生活事件将增加前驱患者患精神病的风险。还评估了重要的协变量，包括认知、早期创伤以及药物和物质使用。这项研究将为申请人提供申请 R01 所需的知识和研究经验，以进一步评估前驱患者精神病发作的危险因素、中介因素和标志物。