A LONGITUDINAL STUDY OF CEREBRAL AND NEUROCOGNITIVE FUNCTION

大脑和神经认知功能的纵向研究

• 批准号: 7952267
• 负责人: ERIC S DAAR
• 金额: $ 9.99万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952267
• 关键词: AIDS neuropathy; Blood; Brain; Brain region; California; Cerebrum; Chemicals; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Enrollment; Funding; Grant; HIV; Institution; Laboratories; Learning; Longitudinal Studies; Magnetic Resonance Spectroscopy; Medical History; Neurocognitive; Neurologic; Neuropsychological Tests; Pharmaceutical Preparations; Pregnancy Tests; Psyche structure; Research; Research Personnel; Resources; Screening procedure; Source; Test Result; Testing; Tissues; United States National Institutes of Health; Visit; Woman; high risk; pregnant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will try to learn more about physical and mental effects of HIV on the brain and determine who may be at a higher risk of difficulties related to the brain. The study will observe the amount of different brain chemicals, and the size of different brain regions by doing an imagining test called magnetic resonance spectroscopy. Results from this test will be compared to neurological and neuropsychological tests completed during this study. Eligible subjects already enrolled in the California NeuroAIDS Tissue Network study will be asked if they are willing to participate in this study. If willing, they will have MRS only performed. The data that is being collected for the CNTN study will be used to compare with the MRS. A screening visit will be done, during which their medication and medical history will be taken, and one tablespoon of blood will be taken for routine laboratory tests. Women will have a pregnancy test and will not participate if pregnant.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将尝试更多地了解HIV对大脑的身体和心理影响，并确定谁可能面临与大脑有关的困难风险。该研究将通过进行想象的测试称为磁共振光谱，观察不同大脑化学物质的量以及不同大脑区域的大小。该测试的结果将与本研究中完成的神经心理学测试进行比较。 将询问已经参加了加利福尼亚神经辅助组织网络研究的合格受试者是否愿意参加这项研究。如果愿意，他们只会表演太太。 CNTN研究正在收集的数据将用于与MRS进行比较。 将进行筛查，在此期间将进行药物和病史，并将一汤匙的血液进行常规的实验室检查。妇女将进行妊娠试验，如果怀孕将不会参加。