The Center for Translational Genomic Phenotyping

转化基因组表型中心

基本信息

批准号：
7923217
负责人：
Robert D Cardiff
金额：
$ 74.16万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7923217
关键词：
Abate Academy Bioinformatics California Cancer Biology Cancer Model Clinical Laboratory Information Systems Collaborations Communication Communities Consultations Country Data Data Display Development Diagnosis Educational workshop Electronics Fostering Genomics Goals Human Image Informatics Intervention Knockout Mice Leadership Malignant Neoplasms Maps Modeling Mouse Models of Human Cancer Consortium Mus Mutant Strains Mice National Cancer Institute Pathologic Pathologist Pathology Phenotype Pilot Projects Pre-Clinical Model Predisposition Prevention Radiology Specialty Research Research Infrastructure Research Project Grants Resources Science Slide Staging System Therapeutic Translations Universities Validation Visit Work authority cancer Biomedical Informatics Grid comparative design experience human disease image archival system in vivo mouse model outreach professor programs repository symposium tool

项目摘要

DESCRIPTION (provided by applicant): The University of California (UC), Davis Center for Translational Genomic Phenotyping (CTGP): A National Cancer Institute-Mouse Models of Human Cancer Consortium (NCI-MMHCC) Science Leadership Application will provide centralized discovery-driven in-vivo and ex-vivo phenotyping for validation of model pathology. This is predominantly centered on Cancer Biology, but Impacts Preventative Interventions, Experimental Therapeutics and Cancer Susceptibility programs as well. The application is organized in five sections. 1. As a Summary of the Research, the PI, Dr. Robert Cardiff, is a Co-Pl, Co-I and collaborator on several past and newly submitted MMHCC research projects. He Is Co-l on "Goal 1" research applications submitted with Lewis Chodosh, Cory Abate-Shen, and Robert Schreiber. He has consistently provided consultation and leadership within the MMHCC Consortium with respect to phenotypes, translation of pathologic findings in the mouse to the human disease, and defining and publicizing criteria for diagnosis, staging and grading critical to the use of the mouse models in cancer biology, prevention, and experimental therapeutics. 2. The Leadership Plan will A) electronically coordinate intra-NCI-MMHCC projects in the specific research clusters of Preventative Interventions and Cancer Biology and anticipate fostering collaborations among the U0l awardees who are affiliated with these research clusters; B) foster collaborations throughout the MMHCC and with other NCI networks and consortia to delineate research resources or pilot projects that promote the cluster collaborations; and C) manage and enhance the existing NCI cancer model bioinformatics infrastructure through caELMIR with Integrated image archives of in-vivo and ex-vivo images that are accurately mapped to relevant human bioinformatics systems in collaboration. 3. The Communication and Coordination will be achieved through the informatics tools connecting the MMHCC research affiliates with the expert pathology/phenotyping resource embodied In the Academy for Genomic Pathology. This group constitutes most of the leading authorities and most experienced mouse model and comparative pathologists in the country. 4. Outreach will be achieved through symposia and workshops, as well as an open visiting trainee/ visiting professor program at the UC Davis center. In addition, the connections at UC Davis to the Mutant Mouse Regional Resource Center, and the Knockout Mouse Project Repository provide added outreach to the mouse modeling community. 5. Pre-Clinical Models Informatics for the MMHCC and the NCI has been developed, in part, by our group at UC Davis. Studies have been Initiated at UC Davis, and specific pilot projects designs demanding accurate integrated data from mouse colony management, pathology laboratory information systems, whole slide images, radiology image data and display and electronic "lab notebooks" using caELMIR, caMOD, and the caBIG infrastructure. This application is uniquely relevant to the program priorities. This is a Leadership U01 centered on phenotyping and pathology, with extensive support from a host of national experts In mouse pathology, and extensive background and preliminary work In development of Informatics uniquely designed to the purposes of the MMHCC consortium

描述（由申请人提供）：加州大学 (UC) 戴维斯转化基因组表型中心 (CTGP)：国家癌症研究所-人类癌症小鼠模型联盟 (NCI-MMHCC) 科学领导力应用程序将提供集中的发现驱动用于验证模型病理学的体内和离体表型分析。这主要集中在癌症生物学，但也影响预防干预、实验治疗和癌症易感性计划。该应用程序分为五个部分。 1. 作为研究摘要，PI Robert Cardiff 博士是多个过去和新提交的 MMHCC 研究项目的 Co-Pl、Co-I 和合作者。他与 Lewis Chodosh、Cory Abate-Shen 和 Robert Schreiber 一起提交了“目标 1”研究申请。他一直在 MMHCC 联盟内提供咨询和领导，涉及表型、将小鼠病理结果转化为人类疾病，以及定义和公布对于在癌症生物学中使用小鼠模型至关重要的诊断、分期和分级标准、预防和实验治疗。 2. 领导计划将 A) 以电子方式协调预防性干预和癌症生物学特定研究集群中的 NCI-MMHCC 内部项目，并预期促进隶属于这些研究集群的 U0l 获奖者之间的合作； B) 促进整个 MMHCC 以及与其他 NCI 网络和联盟的合作，以确定促进集群合作的研究资源或试点项目； C) 通过 caELMIR 管理和增强现有的 NCI 癌症模型生物信息学基础设施，其中体内和离体图像的集成图像档案可准确映射到协作的相关人类生物信息学系统。 3. 沟通和协调将通过连接 MMHCC 研究附属机构与基因组病理学学院包含的专家病理学/表型资源的信息学工具来实现。该小组由国内大多数领先权威和最有经验的小鼠模型和比较病理学家组成。 4. 外展活动将通过研讨会和讲习班以及加州大学戴维斯分校中心的开放访问实习生/访问教授计划来实现。此外，加州大学戴维斯分校与突变小鼠区域资源中心和淘汰小鼠项目存储库的联系为小鼠建模社区提供了更多的服务。 5. MMHCC 和 NCI 的临床前模型信息学部分由我们加州大学戴维斯分校的团队开发。加州大学戴维斯分校已启动研究，具体的试点项目设计要求使用 caELMIR、caMOD 和 caBIG 从小鼠群体管理、病理实验室信息系统、整个幻灯片图像、放射学图像数据和显示以及电子“实验室笔记本”中获得准确的综合数据基础设施。该应用程序与计划优先事项具有独特的相关性。这是一个以表型和病理学为中心的领导 U01，得到了许多国家小鼠病理学专家的广泛支持，以及专门为 MMHCC 联盟的目的而设计的信息学开发方面的广泛背景和前期工作