SIMIAN VARICELLA VIRUS INFECTION AND LATENCY IN THE NONHUMAN PRIMATE

非人类灵长类动物中的猿水痘病毒感染和潜伏期

• 批准号: 7958580
• 负责人: VICKI L TRAINA-DORGE
• 金额: $ 5.8万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958580
• 关键词: Acute; Animals; Cercopithecus pygerythrus; Chickenpox; Clinical; Computer Retrieval of Information on Scientific Projects Database; Dose; Funding; Grant; Herpesvirus Type 3; Housing; Human; Immunosuppressive Agents; Institution; Monkeys; Partner in relationship; Pharmaceutical Preparations; Phase; Prednisone; Primates; Process; Research; Research Personnel; Resources; Roentgen Rays; Sampling; Source; Tacrolimus; United States National Institutes of Health; Viral load measurement; Virus; Virus Diseases; irradiation; nonhuman primate; research study; simian virus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Simian varicella virus (SVV) infection of primates shares clinical, pathological, immunological and virological features of varicella zoster virus (VZV) infection of humans. Latent SVV infection can be established in cynomologous or African green monkeys (AGM) by exposing SVV-seronegative monkeys to an SVV infected cage-mate monkey. This year we conducted portions of three experiments with AGMs. Two groups were latently infected with simian varicella virus (SVV) and treated for possible reactivation utilizing two different treatments. Animals GV . were only irradiated with a single dose (200cGy of X-rays, animals HC were were irradiated with a single dose (200 cGy) of X-irradiation and then treated with tacrolimus (80-300 mg/kg/day). The third group of animals were group housed and one animal from every group acutely infected with SVV. This group passed the acute phase and is in the process of developing latency. In three months, this final group will undergo irradiation, as described above, and be given daily treatment with the immunosuppressive drug, prednisone (1 mg/kg/day), as a possible trigger of virus reactivation. Samples taken are being analyzed for virus load, histopathological changes and evidence of SVV reactivation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 灵长类动物感染的猿猴病毒（SVV）具有人类水痘带状疱疹病毒（VZV）感染的临床，病理，免疫和病毒学特征。 可以通过将SVV-Seronegativate Monkeys暴露于SVV感染的Cage-Mate-Mate猴子中，以C雌性或非洲绿猴（AGM）建立潜在的SVV感染。 今年，我们通过AGM进行了三个实验的一部分。两组被猿猴水痘病毒（SVV）潜在地感染，并通过两种不同的治疗方法进行了重新激活治疗。动物GV。仅被一个单剂量（200克X射线，动物HC辐射，用单剂量（200 CGY）的X辐照辐射，然后用他克莫司（80-300 mg/kg/kg/day）进行治疗。第三组动物被饲养的小组，并从该小组中明确感染了这一阶段。如上所述，接受免疫抑制药物，泼尼松（1 mg/kg/day）的日常治疗，作为病毒重新激活的可能触发。